Time Point (hr) | Mixed Model Statistical Analysis | SKAMP-D | SKAMP-A | SKAMP-Total | SKAMP-QoL | PERMP-A | PERMP-C | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | F Value | P Value | F Value | P Value | F Value | P Value | F Value | P Value | F Value | P Value | F Value | P Value |
-0.5 | Treatment | 0.99 | .3230 | 7.21 | .0084 | 28.52 | <.0001 | 93.12 | <.0001 | 22.19 | <.0001 | 23.58 | <.0001 |
 | Sex | 9.36 | .0028 | 8.71 | .0039 | 13.38 | .0004 | 0.75 | .3891 | 0.31 | .5809 | 0.25 | .6164 |
 | Treatment by sex | 1.95 | .1657 | 0.19 | .6620 | 2.49 | .1173 | 0.52 | .4714 | 0.59 | .4447 | 0.76 | .3861 |
1.5 | Treatment | 19.58 | <.0001 | 12.45 | .0006 | 28.01 | <.0001 | 1.06 | .3049 | 13.67 | .0003 | 19.73 | <.0001 |
 | Sex | 6.59 | .0116 | 3.50 | .0639 | 7.84 | .0060 | 3.72 | .0562 | 0.37 | .5421 | 0.48 | .4899 |
 | Treatment by sex | 0.00 | .9779 | 0.10 | .7528 | 0.20 | .6578 | 0.88 | .3493 | 0.05 | .8245 | 0.39 | .5315 |
2.5 | Treatment | 70.77 | <.0001 | 53.15 | <.0001 | 131.44 | <.0001 | 43.18 | <.0001 | 60.11 | <.0001 | 65.68 | <.0001 |
 | Sex | 7.89 | .0059 | 2.35 | .1278 | 8.72 | .0038 | 2.88 | .0928 | 0.39 | .5326 | 0.39 | .5350 |
 | Treatment by sex | 2.71 | .1023 | 0.81 | .3708 | 2.97 | .0875 | 0.15 | .6995 | 1.10 | .2975 | 1.62 | .2063 |
5.0 | Treatment | 74.56 | <.0001 | 50.75 | <.0001 | 136.60 | <.0001 | 68.23 | <.0001 | 73.30 | <.0001 | 76.40 | <.0001 |
 | Sex | 7.13 | .0087 | 2.58 | .1111 | 7.00 | .0093 | 0.20 | .6518 | 0.23 | .6357 | 0.18 | .6708 |
 | Treatment by sex | 2.50 | .1166 | 1.33 | .2517 | 1.63 | .2049 | 0.28 | .5949 | 1.18 | .2801 | 1.40 | .2398 |
7.5 | Treatment | 67.32 | <.0001 | 56.67 | <.0001 | 137.48 | <.0001 | 53.75 | <.0001 | 89.27 | <.0001 | 92.70 | <.0001 |
 | Sex | 9.38 | .0028 | 3.52 | .0633 | 11.68 | .0009 | 10.46 | .0016 | 1.65 | .2021 | 1.73 | .1916 |
 | Treatment by sex | 4.31 | .0402 | 2.10 | .1506 | 4.16 | .0438 | 0.24 | .6248 | 0.92 | .3406 | 0.76 | .3855 |
10 | Treatment | 44.74 | <.0001 | 39.70 | <.0001 | 92.89 | <.0001 | 17.42 | <.0001 | 64.41 | <.0001 | 69.95 | <.0001 |
 | Sex | 8.67 | .0039 | 5.07 | .0263 | 13.35 | .0004 | 3.22 | .0754 | 0.65 | .4233 | 0.69 | .4083 |
 | Treatment by sex | 1.51 | .2222 | 3.67 | .0579 | 6.31 | .0135 | 2.86 | .0939 | 5.43 | .0217 | 4.98 | .0277 |
12 | Treatment | 21.05 | <.0001 | 30.04 | <.0001 | 69.72 | <.0001 | 26.38 | <.0001 | 47.55 | <.0001 | 52.36 | <.0001 |
 | Sex | 14.36 | .0002 | 2.33 | .1299 | 12.84 | .0005 | 0.67 | .4165 | 0.34 | .5613 | 0.36 | .5484 |
 | Treatment by sex | 0.93 | .3374 | 0.37 | .5455 | 0.55 | .4586 | 0.31 | .5767 | 1.32 | .2524 | 1.42 | .2357 |
13 | Treatment | 3.70 | .0568 | 19.09 | <.0001 | 21.25 | <.0001 | 8.13 | .0052 | 39.39 | <.0001 | 41.15 | <.0001 |
 | Sex | 12.45 | .0006 | 2.84 | .0945 | 13.56 | .0004 | 1.53 | .2187 | 1.08 | .3012 | 1.37 | .2439 |
 | Treatment by sex | 1.30 | .2571 | 2.69 | .1039 | 3.03 | .0844 | 0.00 | .9942 | 3.58 | .0609 | 2.74 | .1006 |