Time Point (hr) | Mixed Model Statistical Analysis | SKAMP-D | SKAMP-A | SKAMP-Total | SKAMP-QoL | PERMP-A | PERMP-C | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | F Value | P Value | F Value | P Value | F Value | P Value | F Value | P Value | F Value | P Value | F Value | P Value |
-0.5 | Treatment | 3.69 | .0574 | 10.88 | .0013 | 48.67 | <.0001 | 133.44 | <.0001 | 34.98 | <.0001 | 37.63 | <.0001 |
 | Age | 8.65 | .0040 | 3.55 | .0623 | 5.76 | .0181 | 0.95 | .3307 | 1.49 | .2251 | 1.60 | .2080 |
 | Treatment by age | 0.10 | .7574 | 0.72 | .3971 | 0.31 | .5771 | 0.02 | .9027 | 0.20 | .6580 | 0.17 | .6793 |
1.5 | Treatment | 27.82 | <.0001 | 19.41 | <.0001 | 42.98 | <.0001 | 2.92 | .0903 | 18.95 | <.0001 | 30.00 | <.0001 |
 | Age | 6.83 | .0102 | 6.63 | .0113 | 6.93 | .0097 | 0.03 | .8716 | 0.59 | .4430 | 0.54 | .4627 |
 | Treatment by age | 2.38 | .1255 | 1.91 | .1693 | 2.32 | .1307 | 0.09 | .7625 | 0.49 | .4876 | 0.02 | .8854 |
2.5 | Treatment | 121.66 | <.0001 | 79.31 | <.0001 | 204.35 | <.0001 | 61.19 | <.0001 | 94.10 | <.0001 | 103.60 | <.0001 |
 | Age | 7.25 | .0082 | 3.70 | .0571 | 7.99 | .0056 | 2.49 | .1172 | 0.14 | .7066 | 0.23 | .6303 |
 | Treatment by age | 5.99 | .0159 | 0.01 | .9253 | 1.93 | .1672 | 0.02 | .8971 | 1.74 | .1902 | 1.27 | .2619 |
5.0 | Treatment | 126.22 | <.0001 | 79.64 | <.0001 | 213.18 | <.0001 | 89.58 | <.0001 | 117.59 | <.0001 | 122.97 | <.0001 |
 | Age | 5.20 | .0245 | 6.59 | .0116 | 8.64 | .0040 | 2.49 | .1173 | 0.04 | .8480 | 0.07 | .7974 |
 | Treatment by age | 5.57 | .0201 | 0.49 | .4865 | 4.54 | .0353 | 2.72 | .1018 | 4.41 | .0379 | 4.25 | .0415 |
7.5 | Treatment | 109.78 | <.0001 | 98.23 | <.0001 | 215.28 | <.0001 | 76.54 | <.0001 | 134.00 | <.0001 | 137.53 | <.0001 |
 | Age | 5.27 | .0236 | 6.93 | .0097 | 7.27 | .0081 | 0.00 | .9885 | 0.21 | .6473 | 0.35 | .5544 |
 | Treatment by age | 0.12 | .7342 | 6.55 | .0118 | 2.06 | .1543 | 0.06 | .8090 | 1.55 | .2159 | 1.38 | .2418 |
10 | Treatment | 72.09 | <.0001 | 68.52 | <.0001 | 150.65 | <.0001 | 32.26 | <.0001 | 108.63 | <.0001 | 115.45 | <.0001 |
 | Age | 3.26 | .0736 | 11.15 | .0011 | 7.22 | .0083 | 0.23 | .6300 | 0.60 | .4393 | 0.64 | .4271 |
 | Treatment by age | 0.83 | .3636 | 0.04 | .8433 | 0.05 | .8172 | 1.00 | .3186 | 0.20 | .6556 | 0.05 | .8202 |
12 | Treatment | 34.82 | <.0001 | 44.84 | <.0001 | 100.99 | <.0001 | 30.71 | <.0001 | 74.62 | <.0001 | 81.57 | <.0001 |
 | Age | 5.34 | .0227 | 9.44 | .0027 | 12.67 | .0006 | 3.97 | .0487 | 0.13 | .7163 | 0.06 | .8065 |
 | Treatment by age | 0.42 | .5170 | 0.06 | .8007 | 0.00 | .9549 | 1.06 | .3058 | 0.27 | .6020 | 0.13 | .7158 |
13 | Treatment | 8.29 | .0048 | 34.69 | <.0001 | 38.63 | <.0001 | 10.26 | .0018 | 67.42 | <.0001 | 68.29 | <.0001 |
 | Age | 5.56 | .0201 | 7.40 | .0076 | 9.48 | .0026 | 0.34 | .5637 | 0.03 | .8639 | 0.09 | .7587 |
 | Treatment by age | 0.01 | .9293 | 0.45 | .5018 | 0.45 | .5051 | 2.15 | .1458 | 0.02 | .8820 | 0.02 | .8913 |