Open Access

Patient characteristics, comorbidities, and medication use for children with ADHD with and without a co-occurring reading disorder: A retrospective cohort study

  • Peter M Classi1Email author,
  • Trong K Le1,
  • Sarah Ward1 and
  • Joseph Johnston1
Child and Adolescent Psychiatry and Mental Health20115:38

DOI: 10.1186/1753-2000-5-38

Received: 22 July 2011

Accepted: 6 December 2011

Published: 6 December 2011

Abstract

Background

Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) often have a co-occurring reading disorder (RD). The purpose of this research was to assess differences between children with ADHD without RD (ADHD-only) and those with ADHD and co-occurring RD (ADHD+RD).

Methods

Using data from the U.S. Thomson Reuter Marketscan® Databases for the years 2005 through 2007, this analysis compared the medical records--including patient demographics, comorbidities, and medication use--of children (age < 18) with ADHD-only to those with ADHD+RD.

Results

Patients with ADHD+RD were significantly younger, more likely to have received a procedure code associated with formal psychological or non-psychological testing, and more likely to have been diagnosed with comorbid bipolar disorder, conduct disorder, or depression. They were no more likely to have received an antidepressant, anti-manic (bipolar), or antipsychotic, and were significantly less likely to have received a prescription for a stimulant medication.

Conclusions

Relying on a claims database, there appear to be differences in the patient characteristics, comorbidities, and medication use when comparing children with ADHD-only to those with ADHD+RD.

Keywords

ADHD Reading Disorder medication use comorbidities patient characteristics

Background

The American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), defines reading disorder (RD) as: "[R]eading achievement (i.e. reading accuracy, speed, or comprehension as measured by individually administered standardized tests) that falls substantially below that expected given the individual's chronological age, measured intelligence, and age-appropriate education [1]." While the rate of RD among all school-age children in the United States is an estimated 4% [2], up to nearly one-third (15%-30%) of children with a diagnosis of attention-deficit/hyperactivity disorder (ADHD) have a co-occurring diagnosis of RD [3, 4]. Research has shown that children with ADHD and co-occurring RD (ADHD+RD) exhibit both the deficits in the basic semantics of language processing associated with RD and the higher-order executive function deficits of ADHD [511].

Given the fact that ADHD and RD often co-occur, a growing body of research has examined shared pathophysiological pathways of ADHD and RD. This research has shown that the two disorders share genetic and environmental factors [12, 13], cognitive processes [1416], aspects of brain anatomy and functioning [17], and treatment interventions [18]. These and other studies have also indicated that ADHD+RD may be a unique disorder with features not associated with either ADHD or RD in isolation. For example, children with ADHD and co-occurring reading or other learning disorders have certain social impairments not observed in "pure" ADHD or learning disorder groups, impairments that may lead to a greater likelihood of peer rejection or starting fights [19]. Still other literature indicates that those with ADHD and co-occurring RD or other learning disorders have more pervasive attention and visuomotor problems than those with either ADHD without learning disorders or learning disorders without ADHD [7].

The purpose of the present study was to better understand differences between ADHD patients with and without co-occurring RD, using two patient groups identified from a large managed care health care claims database. The primary objective was to compare these two groups on the basis of demographic characteristics, other comorbid disorders, and pharmacological treatments patterns. A secondary objective -- recognizing that use of medical billing records is a suboptimal means of identifying children with RD -- was to examine the prevalence of a coded diagnosis RD among ADHD patients and to compare this prevalence with other estimates of RD prevalence among ADHD patients from the literature.

Methods

Data for this study came from the U.S. Thomson Reuters Marketscan® Research Databases. These retrospective, claims databases are fully compliant with the Health Insurance and Portability Act (HIPAA) and capture person-specific clinical utilization, expenditures, and enrollment across inpatient, outpatient, prescription drug and carve-out services from a selection of large employers, health plans, and government and public organizations. The databases link paid claims and encounter data to detailed patient information across sites and types of providers over time and include private sector health data from approximately 100 payers and more than 500 million claim records. Data examined for this study spanned the years 2005 through 2007.

To be included in this study an individual had to be identified as having either ADHD-only or ADHD+ RD. In both groups, patients had to be diagnosed with ADHD based upon the receipt of an ICD-9-CM diagnostic code of 314.00 or 314.01 in the 2006 calendar year, with the first such date identified as the index date. In addition, individuals were required to be younger than 18 at index date and to have continuous insurance coverage, including prescription benefit coverage from 12 months prior to the index date (i.e., the pre-period) through 12 months post index date (i.e., the post-period). To enhance comparability between the ADHD only and ADHD+RD cohorts, all children with a diagnosis of mental retardation (ICD-9-CM of 317.xx, 318.xx, and 319.xx), pervasive development disorder (ICD-9-CM of 299.xx), or developmental delays (ICD-9-CM of 315.4x, 315.5x, 315.8x, or 315.9x) at any time from the start of the pre-period through the end of the post-period were excluded, as these diagnoses generally preclude or complicate a diagnosis of RD.

Given the above criteria, patients were then categorized as ADHD-only or ADHD+RD. In the ADHD-only cohort, patients were excluded if they had a diagnosis of RD (based upon receipt of an ICD-9-CM diagnostic code of 315.0x) at any time from the start of the pre-period through the end of the post-period. A total of 97, 703 children met the criteria for inclusion in the ADHD-only cohort.

For inclusion in the ADHD+RD cohort, individuals had to be diagnosed with ADHD and RD during the 2006 calendar year, with the first date of either diagnosis identified as the index date. Patients with an index diagnosis of ADHD were required to have at least one diagnosis of RD over the time period from the start of the pre-period through the end of the post-period. Similarly, those whose index diagnosis was for RD were required to have at least one diagnosis of ADHD from the start of the pre-period through the end of the post period. A total of 265 individuals were included in the ADHD+RD cohort.

The analysis compared patient demographics, comorbidities, and medication use between individuals with ADHD-only and those with ADHD+RD. Patient demographics included age, sex, region of residence, type of insurance coverage, and type of ADHD (with or without hyperactivity), while comorbid conditions included a variety of neuropsychiatric and behavioral conditions. The analysis also examined both medication use and length of therapy for ADHD medications (long-acting stimulants, short-acting stimulants, and non-stimulants) and other classes of medication used to treat psychiatric disorders (anti-depressants, anti-manic agents, antipsychotics, and anxiolytics). Differences in continuous variables were examined using t-statistics, while differences in categorical variables were examined using chi-square statistics. All analyses were conducted using SAS, version 9.1, and findings of P values of < 0.05 were considered statistically significant. As analyses were exploratory in nature, no adjustment for multiple comparisons was undertaken.

Results

In this retrospective claims database, 0.27% of patients with ADHD were found to have a co-occurring RD. Patients in the ADHD-only cohort were older than those in the ADHD+RD cohort. For example, in the ADHD-only cohort, 49.1% of individuals were age 6-11 and 44.0% were age 12-17, while in the ADHD+RD cohort, these percentages were 63.8% and 33.6%, respectively. The majority of patients in both cohorts were male (71.4% and 67.5%), insured via a PPO (30.4% and 30.6%) or an HMO (30.6% and 32.8%), and diagnosed with ADHD with hyperactivity (70.5% and 70.9%). Patients in the ADHD+RD cohort were more likely to have received formal psychological testing (24.5% v 7.8%) or neuropsychological testing (5.7% v 0.9%) in a setting that is associated with insurance reimbursement, compared to patients with ADHD-only (see Table 1).
Table 1

Demographics and Patient Characteristics

Variable

ADHD Only

(N = 97, 703)

ADHD + RD

(N = 265)

 

N

%

N

%

Age*

    

   0-5

6708

6.9

7

2.6

   6-11

47970

49.1

169

63.8

   12-17

43025

44.0

89

33.6

Sex

    

   Male

69735

71.4

179

67.5

   Female

27968

28.6

86

32.5

Insurance Type

    

   Comprehensive

23216

23.8

63

23.8

   Health Maintenance Organization (HMO)

29880

30.6

87

32.8

   Point of Service (POS)

13715

8.4

31

11.7

   Preferred Provider Organization (PPO)

29730

30.4

81

30.6

   Consumer-Driven Health Plan

685

0.7

1

0.4

   Missing/Unknown

477

0.5

2

0.8

U.S. Region

    

   Northeast

5519

5.6

20

7.5

   North Central

16394

16.8

32

12.1

   South

26466

27.1

83

31.3

   West

9357

9.6

16

6.0

   Unknown

39967

40.9

114

43.0

ADHD Diagnosis Type**

    

   ADHD Without Mention of Hyperactivity

28830

29.5

77

29.1

   ADHD With Hyperactivity

68873

70.5

188

70.9

Testing***

    

   Psychological Testing

7665

7.8

65

24.5

   Neuropsychological Testing

873

0.9

15

5.7

* Age measured at index date. Mean age in the ADHD cohort was 10.8 years (std dev = 3.5 years; median = 11 years). Mean age in the ADHD + RD cohort was 10.2 years (std dev = 3.2 years; median = 10 years).

** Index ADHD, first ADHD in post period, or prior period diagnosis closest to the index date, in that order.

***Psychological and Neuropsychological Testing are from prior and post periods.

Comparing comorbid conditions (at the three digit ICD-9-CM level) revealed that individuals with ADHD+RD, compared to those with ADHD-only, were more likely to be diagnosed with bipolar disorder (9.4% v 6.4%; P = 0.043), conduct disorder (15.5% v 11.2%; P = 0.030), depression (14.3% v 9.9%; P < 0.001), and other learning disorders (12.8% v 3.3%; P < 0.001). Examining subcategories of these comorbidities (e.g., the four digit ICD-9-CM level) revealed that children with ADHD+RD were more likely to be diagnosed with oppositional-defiant disorder (11.7% v 8.0%; P = 0.028), major depressive disorder, recurrent episode (5.3% v 3.0%; P = 0.026), and the learning disorder of developmental speech or language disorder (7.9% v 2.2%; P < 0.0001). There was no difference in the two cohorts with regard to frequency of anxiety disorders, psychotic disorders, seizure disorders, or sleep disorders (see Table 2).
Table 2

Selected Comorbidities/Conditions

Comorbidity

ADHD

ADHD + RD

P Value

 

N

%

N

%

 

Anxiety Disorders

1227

1.3

4

1.5

0.580

Bipolar/Mania

6244

6.4

25

9.4

0.043

Conduct Disturbance

10984

11.2

41

15.5

0.030

Depression

9653

9.9

38

14.3

0.015

Learning Disorders

3251

3.3

34

12.8

< 0.001

Eating Disorders

134

0.1

1

0.4

0.306

Personality Disorders

120

0.1

0

0.0

1.000

Psychotic Disorders

869

0.9

5

1.9

0.085

Seizure Disorders

1097

1.1

5

1.9

0.239

Sleep Disorders

1866

1.9

1

0.4

0.069

Tics/Tourette's

689

0.7

0

0.0

0.272

All comorbidities examined from index date through end of post-period.

Based upon univariate analyses with chi-square tests for variables with counts of at least 5 and Fischer's exact test if any cell had less than 5 observations.

The two most commonly prescribed stimulant medications were extended release forms of amphetamine mixed salts (Adderall XR) and methylphenidate (Concerta), while atypical antipsychotics and antidepressants were the non-ADHD psychiatric medications most commonly prescribed. Relative to those with ADHD-only, children with ADHD+RD were significantly less likely to have received any stimulant medication (71.7% v 77.1%; P = 0.036). They were less likely, in particular, to have received the long-acting stimulant (Adderall XR) (23.0% v 31.6%; P = 0.003) or a short-acting amphetamine (4.9% v 9.5%; P = 0.011). There were no differences between the two cohorts with regard to the frequency of prescribing of anti-depressants, anti-manic agents, antipsychotics, or anxiolytics (see Table 3). While the analyses revealed significant differences in the frequency of prescriptions for stimulant medications for children with ADHD+RD compared to those with ADHD-only, among those prescribed such medication there was no difference in average length of prescription over the 12 month post period. Specifically, children with ADHD-only who were prescribed a stimulant received, on average, 6.5 months of therapy, compared to an average of 6.7 months for those with ADHD+RD (P = 0.609). Similarly, there were no differences among users of medications between the two cohorts with regard to average length of therapy for non-stimulants, antidepressants, antipsychotics, or anxiolytics (see Table 4).
Table 3

Medication Use

ADHD Medication

ADHD

ADHD + RD

P Value

 

N

%

N

%

 

Long-Acting Stimulants

     

Adderall XR

30901

31.6

61

23.0

0.003

Concerta

30976

31.7

86

32.5

0.794

Daytrana

2749

2.8

11

4.2

0.189

Focalin XR

8002

8.2

30

11.3

0.064

Metadate CD

5426

5.6

19

7.2

0.251

Metadate ER

193

0.2

0

0.0

1.000

Methylin ER

1083

1.1

5

1.9

0.227

Methylphenidate HCL ER

0

0.0

0

0.0

N/A

Methylphenidate HCL SR

0

0.0

0

0.0

N/A

Ritalin LA

4574

4.7

15

5.7

0.451

Ritalin SR

39

0.0

0

0.0

1.000

Vyvanse

262

0.3

0

0.0

1.000

Total Long-Acting

69623

71.3

181

68.3

0.288

Short-Acting Stimulants

     

Adderall

381

0.4

1

0.4

1.000

Amphetamine Salt Combo

9289

9.5

13

4.9

0.011

Amphetamine/Dextroamph

0

0.0

0

0.0

N/A

Cylert

0

0.0

0

0.0

N/A

Desoxyn

11

0.0

0

0.0

1.000

Dexedrine

27

0.0

0

0.0

1.000

Dexmethylphenidate HCL

109

0.1

1

0.4

0.258

Dextroamphetamine Sulfate

1231

1.3

1

0.4

0.272

Dextrostat

48

0.0

1

0.4

0.124

Dexampex

0

0.0

0

0.0

N/A

Focalin

3098

3.2

11

4.2

0.363

Methamphetamine HCL

0

0.0

0

0.0

N/A

Methylin

4986

5.1

13

4.9

0.884

Methylphenidate HCL

6701

6.9

19

7.2

0.841

Methylphenidate Hcl SA

0

0.0

0

0.0

N/A

Pemoline

10

0.0

0

0.0

1.000

Ritalin

397

0.4

2

0.8

0.293

Provigil

234

0.2

0

0.0

1.000

Total Short-Acting

22739

23.3

54

20.4

0.265

Total Stimulants

75354

77.1

190

71.7

0.036

Non-Stimulants

     

Atomoxetine

13732

14.1

34

12.8

0.567

Bupropion

3486

3.6

10

3.8

0.857

Alpha 2 Agonists

11296

11.6

32

12.1

0.794

Total Non-Stimulants

25506

26.1

65

24.5

0.559

Medications used to treat Other Mental Health Conditions

ADHD

ADHD + RD

P Value

 

N

%

N

%

 

Anti-depressants

     

MAOI's

0

0.0

0

0.0

N/A

Tricyclics

1734

1.8

3

1.1

0.638

SSRI's

9508

9.7

26

9.8

0.965

SNRI's

772

0.8

1

0.4

0.729

Other

5105

5.2

18

6.8

0.252

Total Antidepressants

14966

15.3

43

16.2

0.682

Antimanic (bipolar) agents

7208

7.4

21

7.9

0.734

Antipsychotics

     

Typical

444

0.5

0

0.0

0.638

Atypical

15593

16.0

52

19.6

0.104

Total Antipsychotics

15703

16.1

52

19.6

0.116

Anxiolytics

     

Benzodiazepines

1807

1.8

3

1.1

0.643

Others

2388

2.4

5

1.9

0.557

Total Anxiolytics

3982

4.1

8

3.0

0.385

All comorbidties examined from index date through end of post-period.

Based upon univariate analyses with chi-square tests for variables with counts of at least 5 and Fischer's exact test if any cell had less than 5 observations.

Table 4

Length of Therapy-By Medication Class

Medication Class

ADHD

ADHD + RD

P Value

 

N

Mean

(Months)

SD

Median

(Months)

N

Mean

(Months)

SD

Median

(Months)

 

Long-Acting Stimulants

69623

6.5

3.57

6.5

181

6.4

3.36

6.3

0.722

Short-Acting Stimulants

22739

4.1

3.28

3.0

54

3.2

2.88

2.0

0.053

Any Stimulant

75354

6.7

3.52

6.8

190

6.5

3.33

6.9

0.609

Non-Stimulants

25506

5.8

3.80

5.6

65

5.2

3.53

4.8

0.212

Antidepressants

14966

5.4

3.78

4.8

43

4.8

3.88

3.0

0.303

Antipsychotics

15703

6.4

3.75

6.7

52

6.3

3.67

7.3

0.863

Anxiolytics

3982

1.9

2.83

0.9

8

1.4

1.64

0.8

0.578

N is the total number of patients with non-missing days supply.

T-tests were used to examine differences in mean length of therapy between the two groups.

Discussion

In contrast to the literature that suggests that RD co-occurs in 15-30% of children with ADHD [3, 4], less than 1% of children with ADHD in our study cohort were found to have a co-occurring coded diagnosis of RD. This almost certainly reflects the incomplete ascertainment of reading disorders using administrative claims data and highlights the fact that claims data can provide valid epidemiologic data only to the extent that the conditions of interest are diagnosed, managed and reimbursed in traditional medical settings. Learning disorders, including reading disorders, are typically recognized and managed in an educational rather than a medical setting, and formal assessment typically involves the services of providers not routinely covered by traditional medical insurance (i.e., educational or clinical psychologists and psychometrists, rather than psychiatrists and other physician providers). In contrast, ADHD, while often first recognized at home or in the classroom, is commonly diagnosed by physicians, at least in part because of the availability of effective pharmacological treatment options [20]. Consequently, it should be recognized that our results pertain to a select subset of all children with ADHD and RD, and our findings should be interpreted accordingly.

Despite this caveat, results of this analysis suggest that children with ADHD+RD may differ from those with ADHD alone in several important respects. First, a greater proportion of the ADHD+RD children were 6-11 years old relative to 12-17 years old (63.8% v 33.6%). In contrast, the ADHD-only children were nearly equally distributed in the 6-11 year old and 12-17 year old groups (49.1% v 44.0%). This difference in age distribution may reflect the fact that RD is typically identified when reading instruction begins in school, i.e., either the end of kindergarten or the beginning of first grade [1, 21], whereas ADHD requires the identification of symptoms in multiple domains of functioning (e.g., home, school) before it can be diagnosed [1]. Therefore, as the DSM-IV states: "[M]any individuals are diagnosed [with ADHD] after the symptoms have been present for a number of years, especially in the case of individuals with Predominantly Inattentive Type [1]." Alternatively, this age discrepancy could be a function of the non-representativeness of our ADHD+RD cohort. While we did exclude children with mental retardation, pervasive developmental disorder and other specific developmental delays, it may be the case that our ADHD+RD cohort included children with multiple and/or more complex disorders, a subset of children more likely to come to medical attention at an earlier age.

A large body of literature has provided evidence of a neurological basis for RD [2234]. In the current study, a significantly higher percentage of ADHD+RD children relative to ADHD-only individuals had psychological testing (24.5% v 7.8%) and neuropsychological testing (15% v 0.9%). This finding reflects the following recent statement from the American Academy of Pediatrics et al. that: "Reading involves the integration of multiple factors related to a person's experience, ability, and neurologic functioning.... There is solid scientific evidence that supports the neurologic basis for the phonological coding deficit theory of reading disabilities [35]." Including psychological or neuropsychological testing in the process of diagnosing RD is compliant with current medical guidelines, which state that, "Children with learning disabilities should undergo assessments of their health, development, hearing, and vision and, when appropriate, medical and psychological interventions for associated and related treatable conditions [36]."

This study also revealed significant differences between the ADHD+RD and ADHD-only cohorts relative to comorbidities and medication use. Consistent with previous research showing a strong association between ADHD+RD and antisocial behavioral disorders, including aggression, delinquency, oppositional defiant disorder [34, 37, 38], as well as between RD and internalizing psychiatric disorders, such as depression [34], the ADHD+RD cohort in this study had a higher rate of comorbid illness, including bipolar/mania, conduct disturbance, oppositional defiant disorder, depression, and learning disorders (see Table 2). Parents, educators, and physicians should be watchful for signs of these disorders in children with both ADHD and RD.

Notably, although the patients with ADHD+RD in this study were more likely to be diagnosed with depression, bipolar/mania, or conduct disorder, they were no more likely to be prescribed antidepressant, anti-manic (bipolar), antipsychotic, or any other type of medication. Neither were those with ADHD+RD more likely to be prescribed any of the following non-stimulant medications used in the treatment of ADHD: atomoxetine [39, 40], tricyclic antidepressants [41], or bupropion [42, 43]. Moreover, relative to the ADHD-only group, the children with ADHD+RD were less likely to receive stimulant medication, which is also commonly prescribed for the treatment of ADHD [43]. Although the ADHD+RD group were less likely to be prescribed stimulant medication, those who did receive any medication had the same mean length of therapy as those in the ADHD-only cohort taking that medication (see Table 4).

The findings of this study should be interpreted in the context of the limitations of the study design. First, the use of diagnostic codes to identify individuals is not as rigorous as formal diagnostic assessments for identifying people with ADHD or RD. Because RD may be diagnosed outside of a medical system that is associated with insurance reimbursement claims, use of such a claims database may preclude capturing a large segment of the ADHD+RD population. As mentioned above, this analysis found that less than 1% of individuals with ADHD received a diagnosis of RD, while the literature suggests that RD may co-occur in 15-30% of ADHD patients [3, 4]. In addition, the study focused exclusively on patients with medical and prescription benefit coverage. Given these limitations, the results may not be generalizeable to other populations. Third, as this study was descriptive in nature, it did not control for the impact of differences in patient characteristics (e.g., age distribution, severity of RD or ADHD, etc.) between the two cohorts of children. This limitation, in turn, precluded any inferences about causality. For example, it is possible that the ADHD+RD cohort in this study were prescribed less stimulant medication relative to the ADHD-only cohort due to the fact that they were younger; however, this hypothesis was not testable given the study design.

Additionally, the number of unique physician visits was not captured in this analysis. While it appears that children with ADHD + RD present with more medical conditions and psychiatric comorbidities compared to children with ADHD alone, this may be due in part to the fact that children with ill-defined or complex developmental disorders are seen by multiple physicians and may receive multiple "rule out" diagnoses before receiving an accurate and comprehensive assessment of their condition. Finally, the use of medical claims data precludes the use of patient assessments; as a result, the analysis could not examine quality of life, functioning, or any clinical outcomes.

Conclusions

This retrospective, descriptive analysis revealed significant differences between children with ADHD+RD and those with ADHD-only. In this study, the cohort with ADHD+RD had a higher burden of comorbidity, including a greater likelihood of a comorbid diagnosis of bipolar/mania, conduct disturbance, oppositional defiant disorder, depression, and learning disorders. At the same time, the children with ADHD+RD were no more likely to have been prescribed antidepressant, anti-manic (bipolar), antipsychotic, or any other type of medication, and were less likely to have been prescribed stimulant medication. These findings indicate the need for further research into the epidemiology, treatment and associated outcomes for children with ADHD+RD. They also indicate that the burden of ADHD+RD is unique and substantial. The special characteristics of ADHD+RD should be considered when conducting clinical evaluations and targeted treatment approaches. All results should be interpreted cautiously given the limited ability to ascertain RD using claims data, and future research into RD should focus on developing and using more broadly representative datasets.

Declarations

Acknowledgements

We thank Maureen J Lage and Patricia Platt who provided medical writing on behalf of Eli Lilly and Company.

Authors’ Affiliations

(1)
Eli Lilly and Company, Lilly Corporate Center

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