Table 1 Demographic and baseline characteristics
|  | Midazolam (N = 25) | Esketamine (N = 26) | t | df | P | ||
|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | ||||
Age (years) | 14.6 | 1.3 | 15.0 | 1.4 | − 1.063 | 49 | 0.293 |
Education (years) | 8.5 | 1.4 | 8.8 | 1.6 | − 0.766 | 49 | 0.447 |
Duration of illness (months) | 19.7 | 14.5 | 21.7 | 10.4 | − 0.550 | 49 | 0.585 |
BMI (kg/m2) | 19.5 | 4.1 | 21.1 | 3.3 | − 1.524 | 49 | 0.134 |
MADRS score | 36.1 | 7.4 | 35.5 | 6.5 | 0.298 | 49 | 0.767 |
SSI-5 score | 8.6 | 1.5 | 8.1 | 1.4 | 1.396 | 49 | 0.169 |
Processing speed | 42.2 | 11.6 | 41.2 | 8.8 | 0.364 | 49 | 0.717 |
Working memory | 43.9 | 12.6 | 42.2 | 10.4 | 0.535 | 49 | 0.595 |
Verbal learning | 43.2 | 11.6 | 46.7 | 9.9 | − 1.134 | 49 | 0.262 |
Visual learning | 42.9 | 10.3 | 44.6 | 7.4 | − 0.661 | 49 | 0.512 |
|  | N | % | N | % | χ2 | df | P |
|---|---|---|---|---|---|---|---|
Female | 23 | 92.0 | 22 | 84.6 | 0.670 | 1 | 0.668 |
Current nonsuicidal self-injury | 25 | 100 | 26 | 100 | – | – | – |
Mood disorder in first degree relative | 10 | 40.0 | 7 | 26.9 | 0.981 | 1 | 0.322 |
First in hospital | 15 | 60.0 | 17 | 65.4 | 0.158 | 1 | 0.776 |
First episode | 18 | 72.0 | 20 | 76.9 | 0.163 | 1 | 0.755 |
Current antidepressant | 31 | 100 | 30 | 100 | – | – | – |
 SSRIs | 23 | 92.0 | 20 | 76.9 | 2.191 | 1 | 0.248 |
 SNRIs | 2 | 8.0 | 5 | 19.2 | –a | – | 0.419 |
Current antipsychotic | 12 | 48.0 | 19 | 73.1 | 3.362 | 1 | 0.089 |
Current benzodiazepine | 21 | 84.0 | 16 | 61.5 | 3.229 | 1 | 0.116 |