Table 5 Model parameter
Parameters | Base-case value | Range | Distribution | References |
|---|---|---|---|---|
Age of patient | Under 18 years | Fixed | Fixed | Â |
Cost discount rate per annum | 7.2% | 3.0–10.0% | Fixed | [59] |
Effects discount rate per annum | 5.0% | 3.0–10.0% | Fixed | [60] |
DSA | ||||
 Probability of tolerance in MPH | 0.936 | 0.842–1 | Fixed |  |
 Probability of response in LDX | 0.882 | 0.792–0.968 | Fixed |  |
 Probability of response in MPH | 0.841 | 0.756–0.924 | Fixed |  |
 Probability of tolerance in LDX | 0.959 | 0.863–1 | Fixed |  |
 Utility of response in titration | 0.381 | 0.342–0.418 | Fixed |  |
 Cost of LDX per 1mg ($) | 0.013 | 0.010–0.015 | Fixed |  |
 Cost of MPH per 1mg ($) | 0.004 | 0.003–0.005 | Fixed |  |
 Cost of the physician in LDX ($) | 34.43 | 27.54–41.32 | Fixed |  |
 Cost of hoteling in MPH ($) | 84.36 | 67.48–101.24 | Fixed |  |
 Cost of hoteling in LDX ($) | 6.89 | 5.51–8.26 | Fixed |  |
 Cost of the supplementary medicine in LDX ($) | 11.88 | 9.50–14.25 | Fixed |  |
 Cost of the supplementary medicine in MPH ($) | 41.32 | 33.05–49.58 | Fixed |  |
 Cost of transformation in LDX ($) | 9.74 | 7.79–11.68 | Fixed |  |
 Cost of transformation in MPH ($) | 19.63 | 15.70–23.55 | Fixed |  |
 The utility of nonresponse is tolerated in LDX | 0.68 | 0.612–0.768 | Fixed |  |
 Utility of nonresponse in tolerate in MPH | 0.59 | 0.53–0.65 | Fixed |  |
PSA | ||||
 Utilities | ||||
| Â | mean | SD | Distribution | Â |
  Utility in response to titration in MPH | 0.38 | 0.02 | Normal |  |
  Utility of response in treatment in LDX | 0.85 | 0.08 | Normal | |
  Utility in non-response in titration | 0.68 | 0.03 | Normal | |
  The utility of nonresponse is tolerated in LDX | 0.68 | 0.03 | Normal | |
  Utility of response in treatment in MPH | 0.61 | 0.06 | Normal | |
  Utility of nonresponse in tolerating MPH | 0.59 | 0.05 | Normal |  |
Transitional probabilities used in the 1-year decision tree | ||||
 Probability in response to MPH group | 0.84 | 0.04 | Beta | [39] |
 Probability in response LDX group | 0.88 | 0.05 | Beta | |
 Probability of tolerating response in the LDX group | 0.96 | 0.05 | Beta | |
 Probability of tolerating response in the MPH group | 0.94 | 0.05 | Beta | |
 Cost distribution of LDX ($) | 728 | 110 | Gamma |  |
 Cost distribution of MPH ($) | 886 | 113 | Gamma | |
 LDX daily dose | 51.52 | 2.62 | Normal |  |
 LDX daily dose in titration | 25 | 1.67 | Normal | |
 MPH daily dose | 50.93 | 2.59 | Normal | |