Table 5 Extrapyramidal Symptom Rating Scale Scores in the 13 Subjects With Dyskinesia at Baseline
ESRS Subscale or Item | Possible Range of Scores | Mean Baseline Score (± SD) | Mean Endpoint Score (± SD) | P Value for Change From Baseline* (df, test value) |
|---|---|---|---|---|
Subjective overall rating (items 1–11) | 0–33 | 4.38 ± 3.28 | 3.00 ± 4.02 | 0.2277 (12, T = -1.27) |
Physician's examination for parkinsonism (items 13–30) | 0–108 | 9.85 ± 8.21 | 3.23 ± 3.19 | 0.0161 (12, T = -2.80) |
Physician's examination for akathisia (item 28) | 0–6 | 2.00 ± 1.58 | 0.69 ± 0.95 | 0.0083 (12, T = -3.16) |
Physician's examination for dyskinesia (items 51–57) | 0–42 | 5.46 ± 3.60 | 2.23 ± 3.17 | 0.0166 (12, T = -2.78) |
CGI of severity of parkinsonism (item 59) | 0–8 | 1.08 ± 1.44 | 0.15 ± 0.38 | 0.0395 (12, T = -2.31) |
CGI of severity of dystonia (item 60) | 0–8 | 0.92 ± 1.50 | 0.08 ± 0.28 | 0.0591 (12, T = -2.09) |
CGI of severity of dyskinesia (item 58) | 0–8 | 2.00 ± 1.22 | 0.85 ± 1.41 | 0.0119 (12,T = -2.96) |