Emotional well-being in children and adolescents treated with atomoxetine for attention-deficit/hyperactivity disorder: Findings from a patient, parent and physician perspective using items from the pediatric adverse event rating scale (PAERS)

Wehmeier, Peter M; Schacht, Alexander; Lehmann, Martin; Dittmann, Ralf W; Silva, Susan G; March, John S

doi:10.1186/1753-2000-2-11

Child and Adolescent Psychiatry and Mental Health

Table 4 Baseline ratings and change from baseline at weeks 8 and 24

From: Emotional well-being in children and adolescents treated with atomoxetine for attention-deficit/hyperactivity disorder: Findings from a patient, parent and physician perspective using items from the pediatric adverse event rating scale (PAERS)

Item	Week	Physician rating			Parent rating			Patient rating
		Mean	95% CI	SD	Mean	95% CI	SD	Mean	95% CI	SD
*Items relating to depressed mood*
8	0	0.32	0.26 to 0.39	0.71	0.54	0.45 to 0.63	0.93	0.33	0.26 to 0.40	0.75
	Ch 8	-0.14	-0.22 to -0.05	0.77	-0.25	-0.35 to -0.15	0.96	-0.20	-0.28 to -0.12	0.76
	Ch 24	-0.20	-0.29 to -0.11	0.71	-0.33	-0.45 to -0.21	0.97	-0.23	-0.32 to -0.13	0.75
32	0	0.50	0.42 to 0.58	0.83	0.81	0.71 to 0.91	1.04	0.44	0.34 to 0.53	0.95
	Ch 8	-0.18	-0.28 to -0.09	0.87	-0.31	-0.43 to -0.19	1.08	-0.23	-0.34 to -0.12	0.99
	Ch 24	-0.26	-0.37 to -0.15	0.90	-0.44	-0.57 to -0.31	1.10	-0.15	-0.28 to -0.02	1.03
39	0	0.48	0.40 to 0.57	0.91	0.78	0.68 to 0.89	1.07	0.47	0.38 to 0.56	0.94
	Ch 8	-0.17	-0.27 to -0.07	0.90	-0.28	-0.40 to -0.16	1.11	-0.28	-0.38 to -0.18	092
	Ch 24	-0.28	-0.39 to -0.17	0.90	-0.36	-0.49 to -0.22	1.14	-0.31	-0.43 to -0.19	1.01
*Items relating to self-harm*
20	0	0.07	0.03 to 0.10	0.38	0.11	0.06 to 0.16	0.51	0.08	0.04 to 0.11	0.40
	Ch 8	-0.01	-0.05 to 0.03	0.37	-0.02	-0.07 to 0.02	0.43	0.00	-0.05 to 0.06	0.51
	Ch 24	-0.02	-0.06 to 0.02	0.32	-0.03	-0.09 to 0.02	0.42	-0.02	-0.06 to 0.02	0.34
43	0	0.07	0.03 to 0.10	0.37	0.11	0.06 to 0.16	0.52	0.08	0.04 to 0.12	0.40
	Ch 8	-0.02	-0.07 to 0.03	0.44	-0.01	-0.06 to 0.04	0.47	0.02	-0.02 to 0.06	0.37
	Ch 24	-0.02	-0.06 to 0.03	0.37	-0.03	-0.08 to 0.01	0.39	0.00	-0.05 to 0.05	0.42
*Items relating to irritability/agitation*
16	0	0.98	0.87 to 1.08	1.10	1.27	1.16 to 1.39	1.20	0.61	0.51 to 0.70	1.01
	Ch 8	-0.68	-0.80 to -0.55	1.17	-0.78	-0.91 to -0.65	1.18	-0.36	-0.48 to -0.25	1.07
	Ch 24	-0.69	-0.83 to -0.55	1.16	-0.80	-0.94 to -0.65	1.19	-0.41	-0.54 to -0.27	1.10
26	0	1.41	1.30 to 1.53	1.22	1.79	1.67 to 1.92	1.27	0.66	0.56 to 0.77	1.09
	Ch 8	-0.97	-1.10 to -0.83	1.24	-1.09	-1.24 to -0.95	1.34	-0.42	-0.52 to -0.31	1.00
	Ch 24	-0.93	-1.07 to -0.79	1.18	-1.10	-1.26 to -0.94	1.31	-0.43	-0.56 to -0.30	1.08
42	0	1.32	1.20 to 1.45	1.26	2.00	1.88 to 2.12	1.22	0.93	0.81 to 1.04	1.22
	Ch 8	-0.52	-0.64 to -0.39	1.17	-0.72	-0.86 to -0.57	1.34	-0.43	-0.57 to -0.29	1.26
	Ch 24	-0.55	-0.70 to -0.41	1.18	-0.85	-1.02 to -0.68	1.38	-0.46	-0.62 to -0.30	1.33
*Item relating to drowsiness*
37	0	0.25	0.19 to 0.30	0.61	0.43	0.35 to 0.50	0.81	0.40	0.32 – 0.48	0.85
	Ch 8	-0.08	-0.15 to 0.00	0.71	-0.16	-0.25 to -0.07	0.83	-0.16	-0.26 to -0.07	0.88
	Ch 24	-0.17	-0.24 to -0.10	0.59	-0.25	-0.36 to -0.14	0.88	-0.20	-0.31 to -0.09	0.86
*Item relating to euphoria*
38	0	0.35	0.28 to 0.43	0.77	0.65	0.55 to 0.74	1.00	1.06	0.93 to 1.19	1.33
	Ch 8	-0.14	-0.22 to -0.05	0.83	-0.32	-0.43 to -0.20	1.05	-0.40	-0.56 to -0.25	1.41
	Ch 24	-0.15	-0.25 to -0.06	0.75	-0.40	-0.51 to -0.29	0.92	-0.43	-0.58 to -0.28	1.24

Items: 8 = feeling withdrawn or numb; 32 = sad or low mood/unhappy; 39 = not interested/no enthusiasm; 20 = trying to hurt him or her self; 43 = thinking about or wanting to hurt self; 16 = nervous, tense, or uptight, 26 = feeling restless or keyed up; 42 = angry or irritable/in a bad mood; 37 = drowsy or "out of it, 38 = unusually good mood/super happy. Abbreviations: 0 = Week 0 (Baseline); Ch 8 = change to week 8, Ch 24 = change to Week 24; CI = confidence interval; SD = standard deviation.

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ISSN: 1753-2000

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