Baseline | Change | Vs. Placebo | Subgroup | Treatment by Subgroup | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Measure | Subgroup (yrs) | Tx | N | Mean | SD | Mean | SD | ES | p Valuea | p Valueb | p Valueb |
ADHD-RS Total | 6–7 | ATX | 176 | 42.8 | 7.9 | -14.2 | 13.8 | .77 | < .001 | .001 | .316 |
PBO | 91 | 43.2 | 6.6 | -4.6 | 10.4 | ||||||
8–12 | ATX | 520 | 40.4 | 8.7 | -15.4 | 13.2 | .65 | < .001 | |||
PBO | 303 | 40.0 | 8.2 | -7.3 | 12.0 | ||||||
ADHD-RS Total T-Score | 6–7 | ATX | 176 | 83.3 | 9.6 | -15.2 | 14.8 | .75 | < .001 | .003 | .346 |
PBO | 91 | 83.1 | 8.5 | -4.9 | 11.2 | ||||||
8–12 | ATX | 520 | 81.5 | 11.4 | -16.4 | 14.6 | .63 | < .001 | |||
PBO | 303 | 81.1 | 10.9 | -7.9 | 13.1 | ||||||
ADHD-RS Inattentive | 6–7 | ATX | 176 | 21.9 | 3.8 | -7.2 | 7.5 | .71 | < .001 | .043 | .439 |
PBO | 91 | 22.1 | 3.7 | -2.4 | 5.7 | ||||||
8–12 | ATX | 520 | 22.4 | 3.7 | -8.0 | 7.4 | .59 | < .001 | |||
PBO | 303 | 22.3 | 3.9 | -3.9 | 6.7 | ||||||
ADHD-RS Hyper/Impulsive | 6–7 | ATX | 176 | 20.9 | 5.6 | -7.0 | 7.2 | .76 | < .001 | < .001 | .257 |
PBO | 91 | 21.2 | 4.5 | -2.1 | 5.4 | ||||||
8–12 | ATX | 520 | 18.0 | 6.7 | -7.3 | 7.0 | .62 | < .001 | |||
PBO | 303 | 17.7 | 6.3 | -3.4 | 6.3 | ||||||
CGI-ADHD-S | 6–7 | ATX | 176 | 5.0 | 0.8 | -1.2 | 1.3 | .62 | < .001 | .010 | .800 |
PBO | 91 | 5.0 | 0.7 | -0.5 | 0.9 | ||||||
8–12 | ATX | 520 | 4.9 | 0.8 | -1.4 | 1.3 | .59 | < .001 | |||
PBO | 304 | 4.9 | 0.8 | -0.7 | 1.1 | ||||||
CPRS-R:S ADHD Index | 6–7 | ATX | 83 | 27.5 | 6.0 | -7.1 | 11.2 | .50 | .009 | .723 | .422 |
PBO | 42 | 28.6 | 5.0 | -3.2 | 8.4 | ||||||
8–12 | ATX | 290 | 27.3 | 6.0 | -8.1 | 8.7 | .74 | < .001 | |||
PBO | 188 | 27.1 | 6.1 | -2.1 | 8.5 | ||||||
CPRS-R:S Cognitive | 6–7 | ATX | 83 | 13.7 | 3.5 | -3.6 | 6.0 | .41 | .033 | .614 | .334 |
PBO | 41 | 14.0 | 3.3 | -1.6 | 4.8 | ||||||
8–12 | ATX | 289 | 13.9 | 3.8 | -4.0 | 5.1 | .69 | < .001 | |||
PBO | 188 | 13.9 | 3.8 | -0.8 | 5.2 | ||||||
CPRS-R:S Hyperactive | 6–7 | ATX | 83 | 12.4 | 4.3 | -3.9 | 5.7 | .56 | .004 | .095 | .753 |
PBO | 42 | 13.3 | 3.2 | -1.6 | 4.9 | ||||||
8–12 | ATX | 290 | 10.4 | 5.1 | -4.1 | 4.5 | .72 | < .001 | |||
PBO | 188 | 10.1 | 4.8 | -1.1 | 4.0 | ||||||
CPRS-R:S Oppositional | 6–7 | ATX | 83 | 9.4 | 4.6 | -1.9 | 5.4 | .31 | .104 | .256 | .090 |
PBO | 42 | 8.3 | 5.0 | 0.1 | 3.8 | ||||||
8–12 | ATX | 290 | 8.7 | 4.7 | -1.4 | 4.2 | .05 | .620 | |||
PBO | 188 | 8.8 | 4.6 | -1.2 | 4.1 |