Skip to main content

Advertisement

Table 3 Summary of Treatment-Emergent Adverse Events Reported by at Least 5% of Subjects in Either Age Group

From: Acute atomoxetine treatment of younger and older children with ADHD: A meta-analysis of tolerability and efficacy

  6- and 7-Year Olds   8- to 12-Year Olds   
  ATX PBO   ATX PBO   
  N = 183 N = 95   N = 542 N = 316   
Event n (%) (n) % p Valuea (n) % (n) % p Valuea p Valueb
Abdominal pain upper 34 (18.6) 6 (6.3) .006 83 (15.3) 40 (12.7) .313 .044
Decreased appetite 30 (16.4) 3 (3.2) < .001 82 (15.1) 17 (5.4) < .001 .331
Headache 25 (13.7) 8 (8.4) .243 90 (16.6) 54 (17.1) .850 .214
Vomiting 25 (13.7) 2 (2.1) .001 51 (9.4) 18 (5.7) .068 .053
Cough 18 (9.8) 6 (6.3) .375 18 (3.3) 28 (8.9) < .001 .007
Nausea 13 (7.1) 2 (2.1) .097 42 (7.7) 20 (6.3) .496 .186
Fatigue 12 (6.6) 2 (2.1) .150 39 (7.2) 8 (2.5) .003 .918
Somnolence 12 (6.6) 1 (1.1) .040 50 (9.2) 14 (4.4) .010 .294
Irritability 9 (4.9) 2 (2.1) .342 33 (6.1) 9 (2.8) .034 .924
Pyrexia 9 (4.9) 2 (2.1) .342 15 (2.8) 17 (5.4) .062 .058
Nasopharyngitis 8 (4.4) 4 (4.2) 1.00 26 (4.8) 24 (7.6) .098 .442
Upper respiratory tract infection 8 (4.4) 3 (3.2) .754 16 (3.0) 17 (5.4) .096 .206
Pharyngolaryngeal pain 2 (1.1) 3 (3.2) .342 26 (4.8) 29 (9.2) .014 .687
  1. Abbreviations: ATX = atomoxetine; N, n = number; PBO = placebo.
  2. aP values comparing ATX and PBO within each subgroup are based on Fisher's exact test.
  3. bP values comparing odds ratios between children and adolescent