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Table 1 Genotypes and TDT results of the analysed variants in CNR1. NAAA and MGLL in the AN trios

From: Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa

Gene SNP1,2 Alleles3 major/minor Location Exchange N4 Genotypes (%)5 Allele frequ.6 Transm. rate7 p-value8
      A/A 26 (42.62) A: 0.64   
      A/G 26 (42.62)    
CNR1 rs2180619 -22,959A/G Putative promoter 61 G/G 9 (14.75) G: 0.36 0.49 (G) 1.00
      A/A 16 (26.23) A: 0.55   
      A/T 35 (57.38)    
CNR1 rs806379 -6,274A/T Intron 2 61 T/T 10 (16.39) T: 0.45 0.52 (T) 0.90
      T/T 43 (70.49) T: 0.84   
      T/G 16 (26.23)    
CNR1 rs1535255 -6,215T/G Intron 2 61 G/G 2 (3.28) G: 0.16 0.50 (G) 1.00
      T/T 43 (70.49) T: 0.84   
      T/C 16 (26.23)    
CNR1 rs2023239 -5,489T/C Exon 3 Non-coding 61 C/C 2 (3.28) C: 0.16 0.50 (C) 1.00
      G/G 38 (41.76) G: 0.65   
      G/A 43 (47.25)    
CNR1 rs1049353 1,359G/A Exon 4 Thr453Thr 91 A/A 10 (10.99) A: 0.35 0.59 (A) 0.11
      G/G 33 (54.10) G: 0.75   
      G/A 26 (42.62)    
FAAH rs932816 -272G/A Putative promoter 61 A/A 2 (3.28) A: 0.25 0.39 (A) 0.13
      C/C 40 (66.67) C: 0.80   
      C/A 16 (26.67)    
FAAH rs324420 10,741C/A Exon 3 Thr129Pro 60 A/A 4 (6.67) A: 0.20 0.56 (A) 0.61
      G/G 49 (80.33) G: 0.89   
      G/A 11 (18.03)    
FAAH rs324419 11,966G/A Exon 7 Cys299Cys 61 A/A 1 (1.64) A: 0.11 0.59 (A) 0.52
      G/G 60 (98.36) G: 0.99   
      G/A 1 (1.64)    
FAAH rs873978 13,883G/A Intron 7 61 A/A 0 (0.00) A: 0.01 1.00 (A) 1.00
      C/C 34 (56.67) C: 0.73   
      C/A 20 (33.33)    
FAAH rs2295632 19,542C/A 3'UTR 60 A/A 6 (10.0) A: 0.27 0.42 (A) 0.42
      G/G 34 (56.67) G: 0.75   
      G/A 22 (36.67)    
NAAA rs2292534 368A/G Intron 1 60 A/A 4 (6.67) A: 0.25 0.57 (A) 0.42
      A/A 38 (62.30) A: 0.78   
      A/T 19 (31.15)    
NAAA rs4859567 9,263A/T Intron 3 61 T/T 4 (6.56) T: 0.22 0.43 (T) 0.42
      G/G 36 (60.00) G: 0.78   
      G/T 21 (35.00)    
NAAA rs10518142 19,229G/T Intron 5 60 T/T 3 (5.00) T: 0.22 0.63 (T) 0.13
      C/C 22 (36.07) C: 0.61   
      C/T 31 (50.82)    
NAAA rs6819442 22,995C/T Intron 9 61 T/T 8 (13.11) T: 0.39 0.56 (T) 0.42
      T/T 36 (59.02) T: 0.75   
      T/A 19 (31.15)    
MGLL rs893294 121,143T/A Intron 8 61 A/A 6 (9.84) A: 0.25 0.54 (A) 0.75
  1. 1 All SNPs were tested for Hardy-Weinberg equilibrium (exact p ≥ 0.05); 2 The TGC haplotype comprises the minor alleles of rs806379, rs1535255, and rs2023239; 3 Numbers are given according to genomic entry AL136096.7 and the translation start codon (nt+1 is the A of ATG); SNP alleles correspond to dbSNP http://www.ncbi.nlm.nih.gov/SNP/; 4 Number of anorexia nervosa trios genotyped; 5 Genotype frequencies in the patients with AN; 6 Allele frequencies in the patients with AN; 7 Transmission rate of the minor alleles; 8 for TDT