The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial

Table 2 Patient demographics

Patient characteristic	Total	Fluoxetine	Placebo	P-value*
	N = 34 (100%)	N = 18 (53%)	N = 16 (47%)
Ethnicity, n (%)				.75
White	25 (73%)	14 (78%)	11 (19%)
African American	6 (18%)	3 (17%)	3 (69%)
Other	3 (9%)	1 (5%)	2 (12%)
Age (years), mean ± SD	16.46 ± 1.08	16.55 ± 1.11	16.35 ± 1.08	.61
Gender, n (%)				.18
Female	5 (15%)	4 (22%)	1 (6%)
Male	29 (85%)	14 (78%)	15 (94%)
Current Depressive Disorder
MDD^a	29 (85.3%)	15 (83.3%)	14 (87.5%)	1.0
Other Depressive Disorder^b	5 (14.7%)	3 (16.7%)	2 (12.5%)	.56
Age at onset of depression, mean ± SD	11.41 ± 2.5	11.9 ± 2.7	10.8 ± 2.1	.19
Length of depression, mean ± SD (weeks)	213.1 ± 153.6	185.0 ± 168.3	244.7 ± 133.4	.26
Current comorbid condition, n (%)
ADHD^c	11 (32.4%)	6 (33%)	5 (31.3%)	1.0
Post Traumatic Stress Disorder	2 (5.9%)	1 (5.6%)	1 (6.3%)	1.0
Conduct Disorder	2 (5.9%)	0 (0%)	2 (12.5%)	.21
Current SUD ^d,e
Alcohol	13 (38.2%)	7 (38.9%)	6 (37.5)	1.0
Alcohol Abuse	10 (29.4%)	5 (27.8%)	5 (31.25%)	1.0
Alcohol Dependence	3 (8.8%)	2 (11.1%)	1 (6.25%)
Cannabis	30 (88.2%)	15 (83.3%)	15 (93.8%)	.60
Cannabis Abuse	16 (47%)	9 (50.0%)	7 (43.8%)	.72
Cannabis Dependence	14 (41.2%)	6 (33.3%)	8 (50.0%)
Polysubstance	1 (2.9%)	0 (0%)	1 (6.3%)	.47
Age at onset of SUD ^e , mean ± SD	13.7 ± 1.2	13.8 ± 1.3	13.7 ± 1.3	.86
Length of SUD, mean ± SD (weeks)	117.4 ± 68.7	116.0 ± 72.4	118.9 ± 66.8	.91

^aMajor Depressive Disorder; 2 patients with MDD had a comorbid Dysthymic disorder diagnosis
^b4 patients were diagnosed with Dysthymic Disorder, 3 patients had Depression Not Otherwise Specified
^cAttention Deficit/Hyperactivity Disorder
^dSubstance Use Disorder
^e10 patients had more than one substance use disorder
*Fisher's exact test analyses were used to compare percentages; generalized linear model (GLM) procedures were used for comparisons of continuous variables between treatment groups

ISSN: 1753-2000