Time course of SKAMP-D (closed symbols) and SKAMP-A (open symbols) assessment over the laboratory school day. LS mean (SE) actual scores (top) and change from predose (bottom) for LDX (squares) and placebo (circles) at predose (-0.5 h) and at 1.5, 2.5, 5, 7.5, 10, 12, and 13 h postdose. Scores were compared using a linear mixed model with sequence, period, and treatment as fixed effects and subject within sequence as a random effect. Lower scores denote improvement. *Denotes P < .005 LDX compared with placebo for SKAMP-D. †Denotes P ≤ .001 LDX compared with placebo for SKAMP-A.