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Table 3 WREMB-R evening and morning subscores and GIPD single item scores (mean ± SD, LOCF).

From: Morning and evening behavior in children and adolescents treated with atomoxetine once daily for Attention-Deficit/Hyperactivity Disorder (ADHD): Findings from two 24-week, open-label studies

  Baseline (BL) Week 2 Week 8 Week 24
  N Score N Score Change N Score Change N Score Change
WREMB-R            
Evening subscore (8 items) 418 13.7 ± 5.24 419 8.0 ± 5.57 -5.7 ± 5.43 419 7.1 ± 5.78 -6.6 ± 6.14 419 8.0 ± 6.16 -5.7 ± 6.30
Morning subscore (3 items) 419 4.3 ± 2.49 418 2.4 ± 2.23 -1.8 ± 2.53 419 2.1 ± 2.22 -2.2 ± 2.84 419 2.3 ± 2.37 -1.9 ± 2.83
GIPD            
Difficulties in the morning            
   patient-rated 418 2.5 ± 1.60 418 2.0 ± 1.40 -0.5 ± 1.74 419 1.9 ± 1.35 -0.6 ± 1.80 419 1.9 ± 1.40 -0.6 ± 1.68
   parent-rateda 418 3.4 ± 1.69 393 2.5 ± 1.44 -0.9 ± 1.77 404 2.4 ± 1.55 -1.0 ± 1.97 409 2.5 ± 1.62 -0.9 ± 1.97
   physician-rated 419 3.6 ± 1.58 419 2.5 ± 1.33 -1.1 ± 1.71 419 2.3 ± 1.45 -1.3 ± 1.84 419 2.6 ± 1.57 -1.1 ± 1.82
Difficulties during school            
   patient-rated 417 2.7 ± 1.65 417 2.1 ± 1.34 -0.6 ± 1.66 418 2.1 ± 1.52 -0.6 ± 1.93 418 2.2 ± 1.60 -0.5 ± 2.04
   parent-rateda 415 3.6 ± 1.58 389 2.9 ± 1.48 -0.8 ± 1.75 403 2.8 ± 1.61 -0.9 ± 1.96 408 3.0 ± 1.73 -0.7 ± 2.11
   physician-rated 416 4.0 ± 1.51 419 2.9 ± 1.40 -1.1 ± 1.77 419 2.7 ± 1.60 -1.3 ± 2.00 419 3.0 ± 1.75 -1.0 ± 2.12
Difficulties during homework            
   patient-rated 416 2.7 ± 1.67 417 2.2 ± 1.51 -0.5 ± 1.81 418 2.1 ± 1.50 -0.6 ± 1.91 418 2.2 ± 1.59 -0.5 ± 1.93
   parent-rateda 417 4.0 ± 1.65 390 3.1 ± 1.51 -1.0 ± 1.67 403 3.0 ± 1.63 -1.0 ± 1.97 408 3.0 ± 1.69 -1.0 ± 2.03
   physician-rated 415 4.2 ± 1.56 418 3.0 ± 1.46 -1.2 ± 1.72 419 2.9 ± 1.62 -1.4 ± 1.91 419 3.0 ± 1.68 -1.2 ± 1.99
Difficulties in the evening            
   patient-rated 418 2.5 ± 1.72 419 1.9 ± 1.26 -0.6 ± 1.67 419 1.9 ± 1.32 -0.6 ± 1.86 419 1.9 ± 1.34 -0.6 ± 1.84
   parent-rateda 419 3.8 ± 1.60 394 2.8 ± 1.50 -1.0 ± 1.66 404 2.6 ± 1.52 -1.2 ± 1.79 409 2.7 ± 1.60 -1.1 ± 1.87
   physician-rated 419 4.2 ± 1.47 419 2.8 ± 1.43 -1.4 ± 1.56 419 2.6 ± 1.54 -1.5 ± 1.82 419 2.9 ± 1.72 -1.3 ± 1.85
  1. Change is shown relative to baseline.
  2. BL = baseline, GIPD = Global Impression of Perceived Difficulties, LOCF = last patient carried forward analysis, N = Number of patients, SD = standard deviation, WREMB-R = Weekly Ratings of Evening and Morning Behavior-Revised.
  3. a Post-baseline parent-rated GIPD scores were considered only if rated by the baseline rater.