Morning and evening behavior in children and adolescents treated with atomoxetine once daily for Attention-Deficit/Hyperactivity Disorder (ADHD): Findings from two 24-week, open-label studies

Wehmeier, Peter M; Dittmann, Ralf W; Schacht, Alexander; Helsberg, Karin; Lehmkuhl, Gerd

doi:10.1186/1753-2000-3-5

Child and Adolescent Psychiatry and Mental Health

Table 3 WREMB-R evening and morning subscores and GIPD single item scores (mean ± SD, LOCF).

From: Morning and evening behavior in children and adolescents treated with atomoxetine once daily for Attention-Deficit/Hyperactivity Disorder (ADHD): Findings from two 24-week, open-label studies

	Baseline (BL)		Week 2			Week 8			Week 24
	N	Score	N	Score	Change	N	Score	Change	N	Score	Change
WREMB-R
Evening subscore (8 items)	418	13.7 ± 5.24	419	8.0 ± 5.57	-5.7 ± 5.43	419	7.1 ± 5.78	-6.6 ± 6.14	419	8.0 ± 6.16	-5.7 ± 6.30
Morning subscore (3 items)	419	4.3 ± 2.49	418	2.4 ± 2.23	-1.8 ± 2.53	419	2.1 ± 2.22	-2.2 ± 2.84	419	2.3 ± 2.37	-1.9 ± 2.83
GIPD
Difficulties in the morning
patient-rated	418	2.5 ± 1.60	418	2.0 ± 1.40	-0.5 ± 1.74	419	1.9 ± 1.35	-0.6 ± 1.80	419	1.9 ± 1.40	-0.6 ± 1.68
parent-rated^a	418	3.4 ± 1.69	393	2.5 ± 1.44	-0.9 ± 1.77	404	2.4 ± 1.55	-1.0 ± 1.97	409	2.5 ± 1.62	-0.9 ± 1.97
physician-rated	419	3.6 ± 1.58	419	2.5 ± 1.33	-1.1 ± 1.71	419	2.3 ± 1.45	-1.3 ± 1.84	419	2.6 ± 1.57	-1.1 ± 1.82
Difficulties during school
patient-rated	417	2.7 ± 1.65	417	2.1 ± 1.34	-0.6 ± 1.66	418	2.1 ± 1.52	-0.6 ± 1.93	418	2.2 ± 1.60	-0.5 ± 2.04
parent-rated^a	415	3.6 ± 1.58	389	2.9 ± 1.48	-0.8 ± 1.75	403	2.8 ± 1.61	-0.9 ± 1.96	408	3.0 ± 1.73	-0.7 ± 2.11
physician-rated	416	4.0 ± 1.51	419	2.9 ± 1.40	-1.1 ± 1.77	419	2.7 ± 1.60	-1.3 ± 2.00	419	3.0 ± 1.75	-1.0 ± 2.12
Difficulties during homework
patient-rated	416	2.7 ± 1.67	417	2.2 ± 1.51	-0.5 ± 1.81	418	2.1 ± 1.50	-0.6 ± 1.91	418	2.2 ± 1.59	-0.5 ± 1.93
parent-rated^a	417	4.0 ± 1.65	390	3.1 ± 1.51	-1.0 ± 1.67	403	3.0 ± 1.63	-1.0 ± 1.97	408	3.0 ± 1.69	-1.0 ± 2.03
physician-rated	415	4.2 ± 1.56	418	3.0 ± 1.46	-1.2 ± 1.72	419	2.9 ± 1.62	-1.4 ± 1.91	419	3.0 ± 1.68	-1.2 ± 1.99
Difficulties in the evening
patient-rated	418	2.5 ± 1.72	419	1.9 ± 1.26	-0.6 ± 1.67	419	1.9 ± 1.32	-0.6 ± 1.86	419	1.9 ± 1.34	-0.6 ± 1.84
parent-rated^a	419	3.8 ± 1.60	394	2.8 ± 1.50	-1.0 ± 1.66	404	2.6 ± 1.52	-1.2 ± 1.79	409	2.7 ± 1.60	-1.1 ± 1.87
physician-rated	419	4.2 ± 1.47	419	2.8 ± 1.43	-1.4 ± 1.56	419	2.6 ± 1.54	-1.5 ± 1.82	419	2.9 ± 1.72	-1.3 ± 1.85

Change is shown relative to baseline.
BL = baseline, GIPD = Global Impression of Perceived Difficulties, LOCF = last patient carried forward analysis, N = Number of patients, SD = standard deviation, WREMB-R = Weekly Ratings of Evening and Morning Behavior-Revised.
^a Post-baseline parent-rated GIPD scores were considered only if rated by the baseline rater.

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ISSN: 1753-2000

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