Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials

Table 6 Effect sizes (Cohen's d) of atomoxetine for improving Child Health and Illness Profile-Child Edition scores based on data of the 3 placebo-controlled trials.

	Children		Adolescents		Interaction^a	Overall
CHIP-CE domains and sub-domains	Effect size	p-value	Effect size	p-value	p-value	Effect size	p-value
Total Score	0.357	0.007	0.370	0.068	0.957	0.353	0.002
Satisfaction Domain	0.002	0.988	0.063	0.757	0.801	0.024	0.829
Satisfaction with Health	-0.183	0.169	-0.105	0.606	0.746	-0.159	0.157
Satisfaction with Self	0.183	0.168	0.216	0.287	0.892	0.198	0.080
Comfort Domain	0.166	0.213	0.126	0.534	0.869	0.162	0.150
Physical Comfort	-0.112	0.402	0.127	0.532	0.322	-0.026	0.820
Emotional Comfort	0.295	0.027	0.187	0.357	0.653	0.268	0.018
Restricted Activity	0.044	0.742	-0.242	0.245	0.246	-0.032	0.777
Risk Avoidance Domain	0.371	0.005	0.829	<0.001	0.059	0.489	<0.001
Individual Risk Avoidance	0.411	0.002	0.631	0.002	0.361	0.463	<0.001
Threats to Achievement	0.262	0.050	0.733	<0.001	0.053	0.387	<0.001
Resilience Domain	0.242	0.069	-0.141	0.487	0.112	0.131	0.247
Family Involvement	0.188	0.158	-0.237	0.243	0.078	0.055	0.627
Physical Activity	-0.013	0.921	-0.203	0.315	0.430	-0.062	0.581
Social Problem Solving	0.232	0.083	0.170	0.409	0.799	0.219	0.054
Achievement Domain	0.491	<0.001	0.373	0.078	0.637	0.431	<0.001
Academic Performance	0.410	0.003	0.381	0.072	0.909	0.376	0.001
Peer Relations	0.351	0.008	0.304	0.134	0.845	0.316	0.005

Abbreviations: CHIP-CE, Child Health and Illness Profile-Child Edition
Significant p-values are bolded; ^ainteraction p-values indicate the possible age-effect

ISSN: 1753-2000