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Table 6 Effect sizes (Cohen's d) of atomoxetine for improving Child Health and Illness Profile-Child Edition scores based on data of the 3 placebo-controlled trials.

From: Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials

  Children Adolescents Interactiona Overall
CHIP-CE domains and sub-domains Effect size p-value Effect size p-value p-value Effect size p-value
Total Score 0.357 0.007 0.370 0.068 0.957 0.353 0.002
Satisfaction Domain 0.002 0.988 0.063 0.757 0.801 0.024 0.829
Satisfaction with Health -0.183 0.169 -0.105 0.606 0.746 -0.159 0.157
Satisfaction with Self 0.183 0.168 0.216 0.287 0.892 0.198 0.080
Comfort Domain 0.166 0.213 0.126 0.534 0.869 0.162 0.150
Physical Comfort -0.112 0.402 0.127 0.532 0.322 -0.026 0.820
Emotional Comfort 0.295 0.027 0.187 0.357 0.653 0.268 0.018
Restricted Activity 0.044 0.742 -0.242 0.245 0.246 -0.032 0.777
Risk Avoidance Domain 0.371 0.005 0.829 <0.001 0.059 0.489 <0.001
Individual Risk Avoidance 0.411 0.002 0.631 0.002 0.361 0.463 <0.001
Threats to Achievement 0.262 0.050 0.733 <0.001 0.053 0.387 <0.001
Resilience Domain 0.242 0.069 -0.141 0.487 0.112 0.131 0.247
Family Involvement 0.188 0.158 -0.237 0.243 0.078 0.055 0.627
Physical Activity -0.013 0.921 -0.203 0.315 0.430 -0.062 0.581
Social Problem Solving 0.232 0.083 0.170 0.409 0.799 0.219 0.054
Achievement Domain 0.491 <0.001 0.373 0.078 0.637 0.431 <0.001
Academic Performance 0.410 0.003 0.381 0.072 0.909 0.376 0.001
Peer Relations 0.351 0.008 0.304 0.134 0.845 0.316 0.005
  1. Abbreviations: CHIP-CE, Child Health and Illness Profile-Child Edition
  2. Significant p-values are bolded; ainteraction p-values indicate the possible age-effect