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Table 7 Correlation between Child Health and Illness Profile-Child Edition and ADHD-Rating Scale total score, by age groups based on data of all 5 trials.

From: Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials

  Baseline Endpoint Change from baseline
CHIP-CE n r 95% CI N r 95% CI n r 95% CI
Children          
Total Score 609 -0.350 -0.418 to -0.282 598 -0.527 -0.589 to -0.466 596 -0.534 -0.595 to -0.474
Satisfaction Domain 604 -0.070 -0.153 to 0.013 598 -0.250 -0.327 to -0.174 591 -0.319 -0.396 to -0.242
Satisfaction with Health 604 0.006 -0.079 to 0.090 598 -0.153 -0.231 to -0.075 591 -0.228 -0.313 to -0.144
Satisfaction with Self 604 -0.133 -0.213 to -0.053 598 -0.305 -0.380 to -0.229 591 -0.340 -0.415 to -0.266
Comfort Domain 609 -0.204 -0.279 to -0.129 598 -0.301 -0.374 to -0.228 596 -0.359 -0.426 to -0.292
Physical Comfort 609 -0.039 -0.117 to 0.039 598 -0.099 -0.175 to -0.022 596 -0.149 -0.224 to -0.074
Emotional Comfort 609 -0.299 -0.368 to -0.230 598 -0.397 -0.468 to -0.032 596 -0.439 -0.503 to -0.375
Restricted Activity 586 -0.019 -0.101 to 0.062 594 -0.068 -0.148 to 0.011 570 -0.080 -0.157 to -0.003
Risk Avoidance Domain 608 -0.517 -0.572 to -0.462 598 -0.591 -0.649 to -0.533 595 -0.545 -0.608 to -0.482
Individual Risk Avoidance 609 -0.494 -0.548 to -0.439 597 -0.478 -0.545 to -0.411 595 -0.401 -0.481 to -0.321
Threats to Achievement 607 -0.459 -0.519 to -0.398 598 -0.571 -0.628 to -0.514 594 -0.526 -0.590 to -0.463
Resilience Domain 609 -0.042 -0.116 to 0.033 597 -0.284 -0.361 to -0.208 595 -0.205 -0.289 to -0.120
Family Involvement 609 -0.018 -0.093 to 0.057 597 -0.195 -0.272 to -0.118 595 -0.163 -0.240 to -0.087
Physical Activity 609 0.150 0.072 to 0.227 597 -0.103 -0.183 to -0.023 595 -0.043 -0.120 to 0.034
Social Problem Solving 606 -0.170 -0.251 to -0.089 597 -0.261 -0.341 -0.180 592 -0.193 -0.292 to -0.095
Achievement Domain 598 -0.273 -0.345 to -0.201 590 -0.467 -0.535 to -0.399 579 -0.482 -0.550 to -0.413
Academic Performance 598 -0.206 -0.281 to -0.130 589 -0.449 -0.521 to -0.378 578 -0.443 -0.517 to -0.369
Peer Relations 607 -0.204 -0.281 to -0.127 598 -0.288 -0.363 to -0.213 594 -0.321 -0.400 to -0.242
Adolescents          
Total Score 181 -0.349 -0.485 to -0.213 177 -0.535 -0.637 to -0.434 176 -0.503 -0.624 to -0.383
Satisfaction Domain 181 -0.050 -0.188 to 0.088 177 -0.203 -0.345 to -0.061 176 -0.275 -0.435 to -0.115
Satisfaction with Health 180 -0.012 -0.154 to 0.129 177 -0.127 -0.267 to 0.013 176 -0.162 -0.324 to -0.000
Satisfaction with Self 181 -0.074 -0.206 to 0.059 177 -0.239 -0.382 to -0.096 176 -0.310 -0.465 to -0.156
Comfort Domain 180 -0.194 -0.325 to -0.062 177 -0.289 -0.430 to -0.148 175 -0.305 -0.448 to -0.163
Physical Comfort 180 -0.050 -0.182 to 0.082 177 -0.064 -0.208 to 0.080 176 -0.143 -0.293 to 0.007
Emotional Comfort 179 -0.260 -0.392 to -0.128 177 -0.399 -0.526 to -0.272 174 -0.384 -0.505 to -0.262
Restricted Activity 172 -0.047 -0.187 to 0.093 173 -0.107 -0.243 to 0.029 165 -0.063 -0.218 to 0.093
Risk Avoidance Domain 180 -0.537 -0.650 to -0.424 176 -0.567 -0.685 to -0.449 174 -0.384 -0.515 to -0.254
Individual Risk Avoidance 180 -0.446 -0.574 to -0.318 177 -0.424 -0.571 to -0.277 175 -0.182 -0.327 to -0.037
Threats to Achievement 180 -0.504 -0.618 to -0.389 176 -0.570 -0.675 to -0.466 174 -0.381 -0.502 to -0.261
Resilience Domain 180 -0.190 -0.331 to -0.050 177 -0.290 -0.419 to -0.162 175 -0.329 -0.470 to -0.188
Family Involvement 179 -0.023 -0.158 to 0.113 177 -0.171 -0.306 to -0.036 174 -0.207 -0.351 to -0.063
Physical Activity 179 0.029 -0.114 to 0.171 177 0.003 -0.137 to 0.142 175 -0.095 -0.242 to 0.051
Social Problem Solving 180 -0.320 -0.446 to -0.194 176 -0.388 -0.516 to -0.259 174 -0.337 -0.458 to -0.216
Achievement Domain 176 -0.275 -0.408 to -0.142 171 -0.562 -0.661 to -0.462 166 -0.558 -0.672 to -0.444
Academic Performance 175 -0.199 -0.350 to -0.048 171 -0.610 -0.705 to -0.515 165 -0.517 -0.642 to -0.392
Peer Relations 180 -0.223 -0.366 to -0.080 177 -0.296 -0.436 to -0.156 175 -0.331 -0.461 to -0.201
  1. Abbreviations: CHIP-CE, Child Health and Illness Profile-Child Edition; ADHD-RS, Attention Deficit/Hyperactivity Disorder Rating Scale; CI, confidence interval; r, Pearson's correlation coefficient