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Table 2 Mixed Model Analysis by Treatment, Sex, and Treatment by Sex for Predose and Postdose Time Points*

From: Efficacy and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: sex and age effects and effect size across the day

Time Point (hr) Mixed Model Statistical Analysis SKAMP-D SKAMP-A SKAMP-Total SKAMP-QoL PERMP-A PERMP-C
   F Value P Value F Value P Value F Value P Value F Value P Value F Value P Value F Value P Value
-0.5 Treatment 0.99 .3230 7.21 .0084 28.52 <.0001 93.12 <.0001 22.19 <.0001 23.58 <.0001
  Sex 9.36 .0028 8.71 .0039 13.38 .0004 0.75 .3891 0.31 .5809 0.25 .6164
  Treatment by sex 1.95 .1657 0.19 .6620 2.49 .1173 0.52 .4714 0.59 .4447 0.76 .3861
1.5 Treatment 19.58 <.0001 12.45 .0006 28.01 <.0001 1.06 .3049 13.67 .0003 19.73 <.0001
  Sex 6.59 .0116 3.50 .0639 7.84 .0060 3.72 .0562 0.37 .5421 0.48 .4899
  Treatment by sex 0.00 .9779 0.10 .7528 0.20 .6578 0.88 .3493 0.05 .8245 0.39 .5315
2.5 Treatment 70.77 <.0001 53.15 <.0001 131.44 <.0001 43.18 <.0001 60.11 <.0001 65.68 <.0001
  Sex 7.89 .0059 2.35 .1278 8.72 .0038 2.88 .0928 0.39 .5326 0.39 .5350
  Treatment by sex 2.71 .1023 0.81 .3708 2.97 .0875 0.15 .6995 1.10 .2975 1.62 .2063
5.0 Treatment 74.56 <.0001 50.75 <.0001 136.60 <.0001 68.23 <.0001 73.30 <.0001 76.40 <.0001
  Sex 7.13 .0087 2.58 .1111 7.00 .0093 0.20 .6518 0.23 .6357 0.18 .6708
  Treatment by sex 2.50 .1166 1.33 .2517 1.63 .2049 0.28 .5949 1.18 .2801 1.40 .2398
7.5 Treatment 67.32 <.0001 56.67 <.0001 137.48 <.0001 53.75 <.0001 89.27 <.0001 92.70 <.0001
  Sex 9.38 .0028 3.52 .0633 11.68 .0009 10.46 .0016 1.65 .2021 1.73 .1916
  Treatment by sex 4.31 .0402 2.10 .1506 4.16 .0438 0.24 .6248 0.92 .3406 0.76 .3855
10 Treatment 44.74 <.0001 39.70 <.0001 92.89 <.0001 17.42 <.0001 64.41 <.0001 69.95 <.0001
  Sex 8.67 .0039 5.07 .0263 13.35 .0004 3.22 .0754 0.65 .4233 0.69 .4083
  Treatment by sex 1.51 .2222 3.67 .0579 6.31 .0135 2.86 .0939 5.43 .0217 4.98 .0277
12 Treatment 21.05 <.0001 30.04 <.0001 69.72 <.0001 26.38 <.0001 47.55 <.0001 52.36 <.0001
  Sex 14.36 .0002 2.33 .1299 12.84 .0005 0.67 .4165 0.34 .5613 0.36 .5484
  Treatment by sex 0.93 .3374 0.37 .5455 0.55 .4586 0.31 .5767 1.32 .2524 1.42 .2357
13 Treatment 3.70 .0568 19.09 <.0001 21.25 <.0001 8.13 .0052 39.39 <.0001 41.15 <.0001
  Sex 12.45 .0006 2.84 .0945 13.56 .0004 1.53 .2187 1.08 .3012 1.37 .2439
  Treatment by sex 1.30 .2571 2.69 .1039 3.03 .0844 0.00 .9942 3.58 .0609 2.74 .1006
  1. LDX: lisdexamfetamine dimesylate; PERMP: Permanent Product Measure of Performance; PERMP-A: PERMP-Attempted; PERMP-C: PERMP-Correct; SKAMP: Swanson, Kotkin, Agler, M-Flynn, and Pelham; SKAMP-A: SKAMP-Attention; SKAMP-D: SKAMP-Deportment.
  2. *Degrees of freedom (df) = 110 for all analyses except the 7.5-hour postdose time point where df = 109 for all analyses.