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Table 4 Response Probabilities Over Time

From: Time courses of improvement and symptom remission in children treated with atomoxetine for attention-deficit/hyperactivity disorder: analysis of Canadian open-label studies

Endpoint Probability That Endpoint Was Observed at or Before: Expected Week by Which This Percentage of Study Participants Will Have Achieved Endpoint:
  4 weeks 12 weeks 26 weeks 52 weeks 25% 50% 75%
Improvement 0.60 (0.38, 0.79) 0.88 (0.75, 0.95) 0.96 (0.85, 0.99) 1.00 -- 3.7 7.2
Robust Improvement 0.47 (0.30, 0.65) 0.76 (0.60, 0.87) 0.85 (0.67, 0.94) 0.96 (0.87, 0.99) 3.6 4.7 12.0
Remission* 0.30 (0.16, 0.49) 0.59 (0.34, 0.79) 0.77 (0.48, 0.92) 0.85 (0.72, 0.93) 3.7 8.0 23.8
Remission** 0.08 (0.04, 0.16) 0.47 (0.26, 0.70) 0.67 (0.51, 0.80) 0.75 (0.60, 0.85) 5.3 14.3 52.3
  1. Probability with 95% confidence interval.
  2. Remission using two definitions: *final score of ADHDRS-IV-PI ≤18, and **CGI-ADHD-S ≤2. ADHDRS-IV-PI = Attention-Deficit/Hyperactivity Disorder Rating Scale Parent Version: Investigator Administered and Scored; CGI-ADHD-S = Clinical Global Impression of ADHD Severity.