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Table 4 Response Probabilities Over Time

From: Time courses of improvement and symptom remission in children treated with atomoxetine for attention-deficit/hyperactivity disorder: analysis of Canadian open-label studies

Endpoint Probability That Endpoint Was Observed at or Before: Expected Week by Which This Percentage of Study Participants Will Have Achieved Endpoint:
  4 weeks 12 weeks 26 weeks 52 weeks 25% 50% 75%
Improvement 0.60
(0.38, 0.79)
0.88
(0.75, 0.95)
0.96
(0.85, 0.99)
1.00 -- 3.7 7.2
Robust Improvement 0.47
(0.30, 0.65)
0.76
(0.60, 0.87)
0.85
(0.67, 0.94)
0.96
(0.87, 0.99)
3.6 4.7 12.0
Remission* 0.30
(0.16, 0.49)
0.59
(0.34, 0.79)
0.77
(0.48, 0.92)
0.85
(0.72, 0.93)
3.7 8.0 23.8
Remission** 0.08
(0.04, 0.16)
0.47
(0.26, 0.70)
0.67
(0.51, 0.80)
0.75
(0.60, 0.85)
5.3 14.3 52.3
  1. Probability with 95% confidence interval.
  2. Remission using two definitions: *final score of ADHDRS-IV-PI ≤18, and **CGI-ADHD-S ≤2. ADHDRS-IV-PI = Attention-Deficit/Hyperactivity Disorder Rating Scale Parent Version: Investigator Administered and Scored; CGI-ADHD-S = Clinical Global Impression of ADHD Severity.