Individual health-related quality of life (ILC) item scores assessed by (a) parents (P), and (b) patients (children/adolescents [C]). Mean scores at baseline and at study end (week 12) [intention-to-treat, last observation carried forward]. Dx = diagnostic procedures. Tx = therapeutic procedures. The right sides of the bars represent mean baseline values, the left sides mean values at week 12, the numbers mean improvements between both time points.