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Table 1 Demographic data and disease characteristics (by age group).

From: Improved functionality, health related quality of life and decreased burden of disease in patients with ADHD treated with OROS® MPH: is treatment response different between children and adolescents?

Age

6-12 years

N = 583

13-18 years

N = 239

All patients

N = 822

U-test1

Chi2-test2

Gender, n (%)

   

p = 0.4602

   Female

84 (14.41)

40 (16.74)

124 (15.09)

 

   Male

499 (85.59)

199 (83.26)

698 (84.91)

 

Age at study start (years)

    

   mean ± SD

9.75 ± 1.59

14.38 ± 1.29

11.10 ± 2.58

p < 0.0011

   minimum, median, maximum

6,10,12

13,14,18

6,11,18

 

Age at study start (years) by group, n (%)

    

   6-9

251 (43.05)

0 (0.00)

251 (30.54)

 

   10-12

332 (56.95)

0 (0.00)

332 (40.39)

 

   13-15

0 (0.00)

197 (82.43)

197 (23.97)

 

   16-18

0 (0.00)

42 (17.57)

42 (5.11)

 

Age at first diagnosis of disease (years)

   

p < 0.0011

   valid N

565

220

785

 

   mean ± SD

7.31 ± 1.85

9.97 ± 2.86

8.06 ± 2.49

 

   minimum, median, maximum

2,7,12

1.0,10.0,16.0

1.0,8.0,16.0

 

Duration of disease at study start (years)

   

p < 0.0011

   valid N

565

220

785

 

   mean ± SD

2.41 ± 1.56

4.27 ± 2.71

2.93 ± 2.12

 

   minimum, median, maximum

0.03,2.1,7.9

0.17,3.8,12

0.03,2.51, 12

 

Diagnosis of ADHD (ICD-10) n (%)3

    

   F90.0: disturbance of activity and attention

364 (62.44)

155 (64.85)

519 (63.14)

p = 0.5672

   F90.1: hyperkinetic conduct disorder

227 (38.94)

89 (37.24)

316 (38.44)

p = 0.7072

   F90.8: other hyperkinetic disorder

8 (1.37)

6 (2.51)

14 (1.70)

p = 0.3962

   F90.9: hyperkinetic disorder, unspecified

18 (3.09)

3 (1.26)

21 (2.55)

p = 0.2052

   others

41 (7.03)

24 (10.04)

65 (7.91)

p = 0.2872

Previous and/or concomitant diseases (ICD-10) n (%)3

    

   No

351 (60.21)

145 (60.67)

496 (60.34)

p = 0.9642

   Others

47 (8.06)

26 (10.87)

73 (8.88)

 

   F91.X: conduct disorder

134 (22.98)

53 (22.18)

187 (22.75)

p = 0.2882

   F91: incl. F91.3 oppositional defiant disorder

103 (17.67)

37 (15.48)

140 (17.03)

p = 0.5122

   F41: anxiety disorder

25 (4.29)

7 (2.93)

32 (3.89)

p = 0.5342

   F42: obsessive-compulsive disorder

12 (2.06)

3 (1.26)

15 (1.82)

p = 0.5992

   F1X: substance abuse

0 (0.00)

6 (2.51)

6 (0.73)

p = 0.0012

  1. 1,2 p-values from the corresponding test between age groups: 6-12 years and 13-18 years
  2. 3 multiple responses possible; Chi2-test always yes vs. no