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Table 1 Dosing and Titration Guidelines

From: The treatment of severe child aggression (TOSCA) study: Design challenges

  OROS Methylphenidate Risperidone
Day < 25 kg > 25 kg Day 20-45 kg > 45 kg
     AM PM AM PM
1-4 18 mg 18 mg 1 - 0.5 mg - 0.5 mg
5-7 18 mg 36 mg 4 0.5 mg 0.5 mg 0.5 mg 0.5 mg
8-11 36 mg 54 mg 8 0.5 mg 1.0 mg 0.5 mg 1.0 mg
12-14 54 mg 72 mg 11 - - 1.0 mg 1.0 mg
15+ Maintenance;
Dose reduction
allowed for side effects
15 - - 1.0 mg 1.5 mg
    16 1.0 mg 1.0 mg - -
    18 - - 1.5 mg 1.5 mg
    22 1.0 mg 1.5 mg 1.5 mg 2.0 mg
    29 1.0 mg 1.5 mg 1.5 mg 2.0 mg
  1. The study prescriber could vary from the guidelines as clinically indicated. In particular, the dose could be held constant or reduced for limiting side effects or if the clinical status left no room for further improvement.