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Table 1 Odds ratios in predicting CBCL subscales at age 12

From: Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems – a longitudinal study

  Odds ratio 95.0% CI for odds ratio p-value
Internalizing symptoms ≥ 90th percentile    
  BDNF Val/Met compared to Val/Val 1.37 0.82-2.29 0.24
  BDNF Met/Met compared to Val/Val 0.82 0.19-3.52 0.78
  5HTTLPR s/l compared to l/l 1.78 0.84-3.76 0.13
  5HTTLPR s/s compared to l/l 4.43 2.09-9.38 <0.01
  LITE 1.70 1.04-2.80 0.04
  EPDS screening cut off 10 1.90 0.98-3.68 0.06
  Clinical cut off 13 3.09 1.30-7.34 0.01
  HSCL-25 5.92 3.59-9.77 <0.001
  LSS 4.03 1.95-8.35 <0.001
  Sex 0.63 0.38-1.04 0.07
  Ethnicity 1.93 1.02-3.67 0.04
Anxious depressed ≥ 90th percentile    
  BDNF Val/Met compared to Val/Val 0.99 0.59-1.64 0.96
  BDNF Met/Met compared to Val/Val 0.64 0.15-2.76 0.55
  5HTTLPR s/l compared to l/l 1.10 0.59-2.06 0.76
  5HTTLPR s/s compared to l/l 2.32 1.22-4.42 0.01
  LITE 1.72 1.07-2.72 0.03
  EPDS screening cut off 10 1.84 0.97-3.49 0.06
  Clinical cut off 13 2.72 1.15-6.43 0.02
  HSCL-25 4.76 2.95-7.70 <0.001
  LSS 3.53 1.71-7.28 0.001
  Sex 0.59 0.37-0.96 0.03
  Ethnicity 1.19 0.59-2-39 0.63
Withdrawn depressed ≥ 90th percentile    
  BDNF Val/Met compared to Val/Val 1.53 0.95-2.51 0.80
  BDNF Met/Met compared to Val/Val 0.75 0.17-3.26 0.70
  5HTTLPR s/l compared to l/l 1.27 0.68-2.38 0.46
  5HTTLPR s/s compared to l/l 2.48 1.29-4.77 0.07
  LITE 1.32 0.83-2.10 0.24
  EPDS screening cut off 10 2.04 1.09-3.81 0.03
  Clinical cut off 13 2.68 1.13-6.34 0.02
  HSCL-25 4.54 2.82-7.30 <0.001
  LSS 1.52 0.62-3.69 0.36
  Sex 1.28 0.81-2.03 0.30
  Ethnicity 2.22 1.22-4.01 0.01
Externalizing symptoms ≥ 90th percentile    
  BDNF Val/Met compared to Val/Val 1.28 0.78-2.10 0.33
  BDNF Met/Met compared to Val/Val 1.50 0.51-4.46 0.47
  5-HTTLPR s/l compared to l/l 1.60 0.86-3.01 0.14
  5-HTTLPR s/s compared to l/l 2.40 1.23-4.75 0.01
  LITE 1.62 1.02-2.56 0.04
  EPDS screening cut off 10 2.07 1.13-3.80 0.02
  Clinical cut off 13 2.52 1.07-5.97 0.03
  HSCL-25 5.20 3.26-8.28 <0.001
  LSS 2.07 0.93-4.62 0.08
  Sex 1.86 1.17-2.95 0.01
  Ethnicity 1.89 1.04-3.46 0.04
  1. Note: CI = Confidence Interval, CBCL = Child Behavior Checklist, BDNF = Brain Derived Neurotrophic Factor, 5-HTTLPR = serotonin transporter gene-linked polymorphic region, LITE = Life Incidence of Traumatic Events, EPDS = Edinburgh Postnatal Depression Scale, HSCL-25 = Hopkins Symptom Checklist 25, LSS = Life Stress Score.
  2. Logistic regression. Dependent variables: CBCL (internalizing symptoms, internalizing symptoms divided into 1) anxious depressed and 2) withdrawn depressed, and externalizing symptoms). Independent variables (0 is used as a reference level): LITE (0≤ 2, 1≥3), EPDS (0≤9, 1≥10) and (0≤12, 1≥13), HSCL-25 (0=mean score <1.75, 1= mean score ≥1.75): LSS (0<90th percentile, 1≥90th percentile) sex (0=girls and 1=boys) and ethnicity (0=Swedish 1=2nd generation immigrants).