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Table 1 Odds ratios in predicting CBCL subscales at age 12

From: Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems – a longitudinal study

 

Odds ratio

95.0% CI for odds ratio

p-value

Internalizing symptoms ≥ 90th percentile

   

  BDNF Val/Met compared to Val/Val

1.37

0.82-2.29

0.24

  BDNF Met/Met compared to Val/Val

0.82

0.19-3.52

0.78

  5HTTLPR s/l compared to l/l

1.78

0.84-3.76

0.13

  5HTTLPR s/s compared to l/l

4.43

2.09-9.38

<0.01

  LITE

1.70

1.04-2.80

0.04

  EPDS screening cut off 10

1.90

0.98-3.68

0.06

  Clinical cut off 13

3.09

1.30-7.34

0.01

  HSCL-25

5.92

3.59-9.77

<0.001

  LSS

4.03

1.95-8.35

<0.001

  Sex

0.63

0.38-1.04

0.07

  Ethnicity

1.93

1.02-3.67

0.04

Anxious depressed ≥ 90th percentile

   

  BDNF Val/Met compared to Val/Val

0.99

0.59-1.64

0.96

  BDNF Met/Met compared to Val/Val

0.64

0.15-2.76

0.55

  5HTTLPR s/l compared to l/l

1.10

0.59-2.06

0.76

  5HTTLPR s/s compared to l/l

2.32

1.22-4.42

0.01

  LITE

1.72

1.07-2.72

0.03

  EPDS screening cut off 10

1.84

0.97-3.49

0.06

  Clinical cut off 13

2.72

1.15-6.43

0.02

  HSCL-25

4.76

2.95-7.70

<0.001

  LSS

3.53

1.71-7.28

0.001

  Sex

0.59

0.37-0.96

0.03

  Ethnicity

1.19

0.59-2-39

0.63

Withdrawn depressed ≥ 90th percentile

   

  BDNF Val/Met compared to Val/Val

1.53

0.95-2.51

0.80

  BDNF Met/Met compared to Val/Val

0.75

0.17-3.26

0.70

  5HTTLPR s/l compared to l/l

1.27

0.68-2.38

0.46

  5HTTLPR s/s compared to l/l

2.48

1.29-4.77

0.07

  LITE

1.32

0.83-2.10

0.24

  EPDS screening cut off 10

2.04

1.09-3.81

0.03

  Clinical cut off 13

2.68

1.13-6.34

0.02

  HSCL-25

4.54

2.82-7.30

<0.001

  LSS

1.52

0.62-3.69

0.36

  Sex

1.28

0.81-2.03

0.30

  Ethnicity

2.22

1.22-4.01

0.01

Externalizing symptoms ≥ 90th percentile

   

  BDNF Val/Met compared to Val/Val

1.28

0.78-2.10

0.33

  BDNF Met/Met compared to Val/Val

1.50

0.51-4.46

0.47

  5-HTTLPR s/l compared to l/l

1.60

0.86-3.01

0.14

  5-HTTLPR s/s compared to l/l

2.40

1.23-4.75

0.01

  LITE

1.62

1.02-2.56

0.04

  EPDS screening cut off 10

2.07

1.13-3.80

0.02

  Clinical cut off 13

2.52

1.07-5.97

0.03

  HSCL-25

5.20

3.26-8.28

<0.001

  LSS

2.07

0.93-4.62

0.08

  Sex

1.86

1.17-2.95

0.01

  Ethnicity

1.89

1.04-3.46

0.04

  1. Note: CI = Confidence Interval, CBCL = Child Behavior Checklist, BDNF = Brain Derived Neurotrophic Factor, 5-HTTLPR = serotonin transporter gene-linked polymorphic region, LITE = Life Incidence of Traumatic Events, EPDS = Edinburgh Postnatal Depression Scale, HSCL-25 = Hopkins Symptom Checklist 25, LSS = Life Stress Score.
  2. Logistic regression. Dependent variables: CBCL (internalizing symptoms, internalizing symptoms divided into 1) anxious depressed and 2) withdrawn depressed, and externalizing symptoms). Independent variables (0 is used as a reference level): LITE (0≤ 2, 1≥3), EPDS (0≤9, 1≥10) and (0≤12, 1≥13), HSCL-25 (0=mean score <1.75, 1= mean score ≥1.75): LSS (0<90th percentile, 1≥90th percentile) sex (0=girls and 1=boys) and ethnicity (0=Swedish 1=2nd generation immigrants).