Table 1 Acute, paediatric, active comparator-controlled studies in ADHD
Study acronym | Study design | Start/Stop dates | Study duration (weeks) | Age range (years) | Numbers | Inclusion criteria | Exclusion criteria |
|---|---|---|---|---|---|---|---|
HFBD [19] | DB,MC,PC,R | Nov 1998/Feb | 9 | 7-12 | 65 ATX | ADHD diagnosis, normal intelligence, minimum severity criteria | PMs, <25 kg, history of BPD I/II, psychosis/OBD/seizures,on psychotropic medication, history (3 m) of drug/alcohol abuse, significant prior or current medical conditions |
(Spencer;2002) | 2000 | 62 Pbo | |||||
20 MPH | |||||||
HFBK [19] | DB,MC,PC,R | Nov 1998/Feb | 9 | 7-12 | 64 ATX | ADHD diagnosis, normal intelligence, minimum severity criteria | PMs,<25 kg, history of BPD I/II, psychosis/OBD/seizures, on psychotropic medication, history (3 m) of drug/alcohol abuse, significant prior or current medical conditions |
(Spencer;2002) | 2000 | 62 Pbo | |||||
18 MPH | |||||||
LYAV [20] | CO,DB,R | June | 7 on each treatment with washout in between | 6-14 | 44 ATX | ADHD diagnosis, normal intelligence, minimum severity criteria | SMI, Primary sleep disorder |
(Sangal;2006) | 2001/October | 41 MPH | |||||
2002 | (SP II) | ||||||
LYBI [21] | DB,PC,PG,R, | Aug 2002/Sep | 6 | 6-16 | 222 ATX | ADHD diagnosis, minimum severity criteria | Seizures, BPD, psychosis, PDD, concomitant psychoactive medications, anxiety, tic disorders, lack of response/tolerability issues with previous stimulant usage |
(Spencer;2002) | 2003 | 220 MPH | |||||
74 Pbo (SPII) | |||||||
LYBR [22] | DB, MC, R | Jan 2004/Oct | 8 | 6-16 | 164 ATX | ADHD, 20-60 kg, minimum severity criteria | BPD, psychotic, PDD, suicide risk, other psychoactive medication usage, tics, tourettes,anxiety disorders |
(Wang;2007) | 2004 | 166 MPH |