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Table 2 Assessments and dosing schedule in sertraline step 2

From: The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Week Dose (mg) Range (mg) Assessments Actions
     Check Adverse Events Scale (baseline) (AE), Somatic assessment (SA), Clinical Global Impression (CGI)
0 25 × 3 days, then 50 25-50 CY-BOCS incl. CGI (use CY-BOCS at step 1 session 13 if < 3 weeks, else reassessment in point 10c above), CGAS, blood pressure (BP), pulse, weight, length, side effects (AE) AE, SA, CGI, Clinical Global Impression - Improvement (CGI-I)
2 75 50-75 CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility AE, SA, CGI, CGI-I
3-4 100 75-100 CGI-I, CGI, BP, pulse, weight, length, side effects AE, SA, CGI, CGI-I, dose correction based on response
5-7 150 75-150 CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility, KINDL (“independent rater”) AE, SA, CGI, CGI-I, dose correction on response
8-12 200 75-200 CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility AE, SA, CGI, CGI-I, dose correction based on response
12-16 200 75-200 CY-BOCS incl. CGI/CGI-I, CGAS, Scared-R, MFQ, COIS, FAS, KINDL (“independent rater”), BP, pulse, weight, length, side effects, treatment credibility AE, SA, CGI, CGI-I, dose correction based on response