From: The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods
Week | Dose (mg) | Range (mg) | Assessments | Actions |
---|---|---|---|---|
Check Adverse Events Scale (baseline) (AE), Somatic assessment (SA), Clinical Global Impression (CGI) | ||||
0 | 25 × 3 days, then 50 | 25-50 | CY-BOCS incl. CGI (use CY-BOCS at step 1 session 13 if < 3 weeks, else reassessment in point 10c above), CGAS, blood pressure (BP), pulse, weight, length, side effects (AE) | AE, SA, CGI, Clinical Global Impression - Improvement (CGI-I) |
2 | 75 | 50-75 | CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility | AE, SA, CGI, CGI-I |
3-4 | 100 | 75-100 | CGI-I, CGI, BP, pulse, weight, length, side effects | AE, SA, CGI, CGI-I, dose correction based on response |
5-7 | 150 | 75-150 | CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility, KINDL (“independent rater”) | AE, SA, CGI, CGI-I, dose correction on response |
8-12 | 200 | 75-200 | CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility | AE, SA, CGI, CGI-I, dose correction based on response |
12-16 | 200 | 75-200 | CY-BOCS incl. CGI/CGI-I, CGAS, Scared-R, MFQ, COIS, FAS, KINDL (“independent rater”), BP, pulse, weight, length, side effects, treatment credibility | AE, SA, CGI, CGI-I, dose correction based on response |