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Table 2 Assessments and dosing schedule in sertraline step 2

From: The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Week

Dose (mg)

Range (mg)

Assessments

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Check Adverse Events Scale (baseline) (AE), Somatic assessment (SA), Clinical Global Impression (CGI)

0

25 × 3 days, then 50

25-50

CY-BOCS incl. CGI (use CY-BOCS at step 1 session 13 if < 3 weeks, else reassessment in point 10c above), CGAS, blood pressure (BP), pulse, weight, length, side effects (AE)

AE, SA, CGI, Clinical Global Impression - Improvement (CGI-I)

2

75

50-75

CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility

AE, SA, CGI, CGI-I

3-4

100

75-100

CGI-I, CGI, BP, pulse, weight, length, side effects

AE, SA, CGI, CGI-I, dose correction based on response

5-7

150

75-150

CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility, KINDL (“independent rater”)

AE, SA, CGI, CGI-I, dose correction on response

8-12

200

75-200

CGI-I, CGI, BP, pulse, weight, length, side effects, treatment credibility

AE, SA, CGI, CGI-I, dose correction based on response

12-16

200

75-200

CY-BOCS incl. CGI/CGI-I, CGAS, Scared-R, MFQ, COIS, FAS, KINDL (“independent rater”), BP, pulse, weight, length, side effects, treatment credibility

AE, SA, CGI, CGI-I, dose correction based on response