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Table 2 Cerebellar volume and psychiatric outcome in VLBW participants and controls

From: Mental health and cerebellar volume during adolescence in very-low-birth-weight infants: a longitudinal study

 

Assessed at 15 years

Assessed 19 at years

VLBW (N = 40)

Control (N = 56)

VLBW (N = 44)

Control (N = 60)

Cerebellar volume (ml) M (SD)

 White matter M (SD)

25.52 (4.05)*

28.93 (3.04)

26.60 (4.03)*

29.83 (3.10)

 Gray matter M (SD)

99.46 (11.02)

103.93 (10.08)

96.59 (11.14)

103.57 (8.85)

Psychiatric questionnaires

 CGAS M (SD)

71.73 (14.48)***

86.96 (6.75)

79.05 (12.75)**

85.78 (7.69)

 ASEBA M (SD)

  Internalizing M (SD)

6.95 (5.27)

7.23 (5.96)

10.00 (9.45)

7.33 (7.25)

  Externalizing M (SD)

7.68 (4.74)

8.14 (5.84)

7.25 (4.99)

6.48 (5.78)

  Total problems. M (SD)

25.16 (14.91)

24.59 (15.81)

32.15 (21.53)

26.90 (20.78)

 ADHD-RS-IV

  Hyperactivity M (SD)

2.78 (3.71)

1.43 (1.78)

2.90 (4.29)

1.34 (1.67)

  Inattention M (SD)

6.39 (5.11)***

2.51 (2.81)

5.45 (5.58)**

1.76 (1.98)

Clinical diagnoses

 Any psychiatric diagnosis M (SD)

12 (30)**

3 (5.36)

11 (25)**

4 (6.67)

  Anxiety disorders M (SD)

5 (12.50)

2 (3.57)

7 (15.91)**

1 (1.67)

  ADHD M (SD)

3 (7.50)*

0 (0)

4 (9.09)*

0 (0)

  Other M (SD)

4 (10)

1 (1.76)

0 (0)

3 (5)

 Any subclinical diagnosis n (%)

11 (27.50)***

1 (1.76)

5 (11.36)

6 (10)

  Anxiety n (%)

3 (7.50)

1 (1.76)

4 (9.09)

2 (3.33)

  ADHD n (%)

8 (20)***

0 (0)

1 (2.27)

3 (5)

  Other n (%)

0 (0)

0 (0)

0 (0)

1 (1.67)

 Diagnostic status n (%)

  Healthy/became healthy n (%)

22 (55)**

46 (82)

25 (57)**

50 (83)

  Persisting/developed diagnosis n (%)

18 (45)**

10 (18)

16 (36)*

9 (15)

  1. Linear regression adjusted for age and sex for normal distributed data, else the Mann–Whitney U-test. Cerebellar volumes adjusted for estimated intracranial volume. The unconditional z-pooled test was used to analyze differences in proportions between groups
  2. ADHD-RS-IV attention-deficit/hyperactivity disorder rating scale, ASEBA the Achenbach system of empirically based assessment, YSR (Youth Self Report at 14 years) and ARS (Adult Self Report at 19 years), CGAS children’s global assessment scale, M mean, SD standard deviation, VLBW very low birth weight (birth weight ≤ 1500)
  3. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 (VLBW versus controls)