Table 5 Change in clinical variables at 6 months (linear mixed models)
|  | Group effect | Time effect | Group × time interaction |
|---|---|---|---|
ADOS, mean (±SD) | |||
  Communication score | −0.93 (p = 0.22) | −0.8 (p = 0.016) | 0.16 (p = 0.7) |
  Interaction score | −2.07 (p = 0.071) | −2 (p = 0.008) | 1.07 (p = 0.25) |
  Total score | −3.01 (p = 0.082) | −2.8 (p = 0.001) | 1.23 (p = 0.21) |
Cognitive level (WISC3/WPPSI) | |||
  VIQ | 2.3 (p = 0.8) | 1.7 (p = 0.63) | 2.5 (p = 0.59) |
  PIQ | −0.33 (p = 0.97) | 1.7 (p = 0.64) | 6.66 (p = 0.16) |
  Speed | 2.99 (p = 0.69) | 0.11 (p = 0.98) | 3.7 (p = 0.53) |
  Working memory | 9.85 (p = 0.42) | 2.14 (p = 0.49) | 2.87 (p = 0.56) |
  Total IQ | 2.5 (p = 0.8) | 2.55 (p = 0.46) | 5.61 (p = 0.23) |
SCQ, mean (±SD) | |||
  Total score | 0.071 (p = 0.98) | −2.9 (p = 0.054) | 1.33 (p = 0.49) |
Vineland: mean (±SD) | |||
  Communication score | 8.6 (p = 0.14) | 3.2 (p = 0.27) | −5.2 (p = 0.17) |
  Daily living | 4.89 (p = 0.34) | 4.2 (p = 0.19) | −3.06 (p = 0.46) |
  Socialization | 1.2 (p = 0.79) | 7 (p = 0.033) | −6.29 (p = 0.13) |
CBCL T score: mean (±SD) | |||
  Withdrawn/depressed | −0.54 (p = 0.99) | −2.3 (p = 0.22) | 0.38 (p = 0.88) |
  Somatic complaints | −3.5 (p = 0.3) | −2 (p = 0.2) | 0.69 (p = 0.73) |
  Anxious/depressed | 1.57 (p = 0.68) | −2.6 (p = 0.1) | 0.37 (p = 0.86) |
  Social problems | 1.83 (p = 0.58) | −5.89 (p = 0.04) | 1.14 (p = 0.64) |
  Thought problems | −5.58 (p = 0.23) | −5.44 (p = 0.12) | 4.11 (p = 0.37) |
  Attention problems | 2.32 (p = 0.56) | −6.3 (p = 0.011) | 4.84 (p = 0.12) |
  Rule-breaking behavior | 0.47 (p = 0.87) | −0.67 (p = 0.64) | −1.42 (p = 0.46) |
  Aggressive behavior | −4.46 (p = 0.18) | −3.44 (p = 0.054) | 1.23 (p = 0.59) |
  Internalizing | −0.54 (p = 0.89) | −4. (p = 0.018) | 1.77 (p = 0.4) |
  Externalizing | −2.62 (p = 0.48) | −5.8 (p = 0.01) | 4.41 (p = 0.12) |
  Total | −2.58 (p = 0.5) | −6 (p = 0.013) | 3.2 (p = 0.28) |
PSI, mean (±SD) | |||
  Parental distress | −1.51 (p = 0.65) | −5.55 (p = 0.037) | 2.19 (p = 0.5) |
  Dysfunctional interaction | −2.13 (p = 0.5) | −5.68 (p = 0.065) | 0.61 (p = 0.87) |
  Difficult child | −2.67 (p = 0.4) | −9.59 (p < 0.001) | 1.8 (p = 0.41) |
  Total stress | −6.4 (p = 0.42) | −20.92 (p = 0.002) | 5.7 (p = 0.47) |