Skip to main content

Advertisement

Table 5 Change in clinical variables at 6 months (linear mixed models)

From: GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study

  Group effect Time effect Group × time interaction
ADOS, mean (±SD)
  Communication score −0.93 (p = 0.22) −0.8 (p = 0.016) 0.16 (p = 0.7)
  Interaction score −2.07 (p = 0.071) −2 (p = 0.008) 1.07 (p = 0.25)
  Total score −3.01 (p = 0.082) −2.8 (p = 0.001) 1.23 (p = 0.21)
Cognitive level (WISC3/WPPSI)
  VIQ 2.3 (p = 0.8) 1.7 (p = 0.63) 2.5 (p = 0.59)
  PIQ −0.33 (p = 0.97) 1.7 (p = 0.64) 6.66 (p = 0.16)
  Speed 2.99 (p = 0.69) 0.11 (p = 0.98) 3.7 (p = 0.53)
  Working memory 9.85 (p = 0.42) 2.14 (p = 0.49) 2.87 (p = 0.56)
  Total IQ 2.5 (p = 0.8) 2.55 (p = 0.46) 5.61 (p = 0.23)
SCQ, mean (±SD)
  Total score 0.071 (p = 0.98) −2.9 (p = 0.054) 1.33 (p = 0.49)
Vineland: mean (±SD)
  Communication score 8.6 (p = 0.14) 3.2 (p = 0.27) −5.2 (p = 0.17)
  Daily living 4.89 (p = 0.34) 4.2 (p = 0.19) −3.06 (p = 0.46)
  Socialization 1.2 (p = 0.79) 7 (p = 0.033) −6.29 (p = 0.13)
CBCL T score: mean (±SD)
  Withdrawn/depressed −0.54 (p = 0.99) −2.3 (p = 0.22) 0.38 (p = 0.88)
  Somatic complaints −3.5 (p = 0.3) −2 (p = 0.2) 0.69 (p = 0.73)
  Anxious/depressed 1.57 (p = 0.68) −2.6 (p = 0.1) 0.37 (p = 0.86)
  Social problems 1.83 (p = 0.58) −5.89 (p = 0.04) 1.14 (p = 0.64)
  Thought problems −5.58 (p = 0.23) −5.44 (p = 0.12) 4.11 (p = 0.37)
  Attention problems 2.32 (p = 0.56) −6.3 (p = 0.011) 4.84 (p = 0.12)
  Rule-breaking behavior 0.47 (p = 0.87) −0.67 (p = 0.64) −1.42 (p = 0.46)
  Aggressive behavior −4.46 (p = 0.18) −3.44 (p = 0.054) 1.23 (p = 0.59)
  Internalizing −0.54 (p = 0.89) −4. (p = 0.018) 1.77 (p = 0.4)
  Externalizing −2.62 (p = 0.48) −5.8 (p = 0.01) 4.41 (p = 0.12)
  Total −2.58 (p = 0.5) −6 (p = 0.013) 3.2 (p = 0.28)
PSI, mean (±SD)
  Parental distress −1.51 (p = 0.65) −5.55 (p = 0.037) 2.19 (p = 0.5)
  Dysfunctional interaction −2.13 (p = 0.5) −5.68 (p = 0.065) 0.61 (p = 0.87)
  Difficult child −2.67 (p = 0.4) −9.59 (p < 0.001) 1.8 (p = 0.41)
  Total stress −6.4 (p = 0.42) −20.92 (p = 0.002) 5.7 (p = 0.47)
  1. ADOS Autism Diagnostic Observation Schedule, WISC 3 Wechsler Intelligence Scale for Children 3, WPPSI Wechsler Preschool and Primary Scale of Intelligence, VIQ Verbal Intelligent Quotient, PIQ Performance Intelligent Quotient, CBCL Child Behaviour Checklist