Quality of life in children and adolescents with bipolar I depression treated with olanzapine/fluoxetine combination

Table 2 Changes in KINDL-R patient-rated scale from baseline to endpoint (last observation carried forward)

KINDL-R domains	OFC			Placebo			Between-group p value^a
KINDL-R domains	N	Mean baseline (SD)	LS mean change (SE)	N	Mean baseline (SD)	LS mean change (SE)	Between-group p value^a
Total	107	51.2 (15.6)	12.8 (1.7)	40	45.2 (13.2)	7.9 (2.4)	0.050
Physical well-being	151	54.9 (20.1)	12.8 (2.2)	70	54.4 (20.4)	12.4 (2.8)	0.873
Emotional well-being	150	53.3 (22.9)	13.7 (2.1)	70	51.0 (23.3)	11.1 (2.7)	0.330
Self-esteem	150	36.9 (26.7)	18.2 (2.7)	69	32.3 (20.9)	10.7 (3.4)	0.028
Family	147	58.2 (21.1)	9.6 (2.0)	68	55.5 (21.6)	9.6 (2.6)	0.994
Friends	147	52.8 (25.0)	14.8 (2.5)	62	47.9 (24.6)	12.2 (3.2)	0.427
School	110	46.9 (17.8)	6.5 (2.3)	44	46.6 (17.5)	4.6 (3.3)	0.559
Disease	10	41.7 (14.6)	12.3 (7.2)	3	36.1 (27.7)	−9.8 (13.6)	0.152

KINDL-R KINDL questionnaire for measuring health-related quality of life in children and adolescents, LS least squares, N number of patients, OFC olanzapine/fluoxetine combination, SD standard deviation, SE standard error
^aDifference between LS mean change scores

ISSN: 1753-2000