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Table 3 Changes in KINDL-R parent-rated scale from baseline to endpoint (last observation carried forward)

From: Quality of life in children and adolescents with bipolar I depression treated with olanzapine/fluoxetine combination

KINDL-R domains OFC Placebo Between-group p valuea
N Mean baseline (SD) LS mean change (SE) N Mean baseline (SD) LS mean change (SE)
Total 83 46.7 (12.4) 16.0 (1.9) 39 47.1 (11.5) 10.9 (2.6) 0.066
Physical well-being 146 52.8 (20.0) 13.8 (2.3) 72 55.5 (22.0) 11.7 (2.9) 0.475
Emotional well-being 140 49.2 (20.1) 22.6 (2.3) 71 47.1 (16.7) 15.8 (2.9) 0.020
Self-esteem 144 33.3 (22.1) 20.3 (2.4) 69 29.9 (20.5) 13.6 (3.0) 0.030
Family 146 48.0 (20.5) 18.4 (2.1) 71 55.0 (19.5) 11.0 (2.7) 0.006
Friends 139 51.1 (19.9) 18.2 (2.3) 62 53.9 (20.4) 13.7 (3.0) 0.137
School 94 45.7 (15.0) 9.0 (2.0) 43 49.9 (14.6) 3.7 (2.7) 0.057
Disease 8 53.1 (25.1) 11.0 (7.4) 6 47.2 (30.2) 5.3 (7.9) 0.603
  1. KINDL-R KINDL questionnaire for measuring health-related quality of life in children and adolescents, LS least squares, N number of patients, OFC olanzapine/fluoxetine combination, SD standard deviation, SE standard error
  2. aDifference between LS mean change scores