Table 4 Changes in CDRS-R Item scores from baseline to week 8 (mixed-model repeated measures)
CDRS-R item (Item #) | OFC, N = 170 mean baseline (SD) | OFC, N = 170 LS mean change (SE) | Placebo, N = 84 mean baseline (SD) | Placebo, N = 84 LS mean change (SE) | Between-group p value |
|---|---|---|---|---|---|
Total | 54.6 (10.0) | −28.4 (1.1) | 53.7 (8.2) | −23.4 (1.5) | 0.003 |
Impaired schoolwork (1) | 4.1 (1.4) | −1.92 (0.1) | 4.0 (1.3) | −1.5 (0.2) | 0.019 |
Difficulty having fun (2) | 4.5 (1.2) | −2.7 (0.1) | 4.7 (1.1) | −2.2 (0.2) | 0.023 |
Social withdrawal (3) | 3.9 (1.2) | −2.3 (0.1) | 4.0 (1.2) | −1.8 (0.2) | 0.003 |
Sleep disturbance (4) | 3.4 (1.3) | −2.1 (0.1) | 3.4 (1.3) | −1.3 (0.1) | <.001 |
Appetite disturbance (5) | 2.4 (1.2) | −0.5 (0.1) | 2.7 (1.3) | −0.8 (0.2) | 0.171 |
Excessive fatigue (6) | 4.0 (1.5) | −2.3 (0.1) | 3.9 (1.7) | −2.2 (0.2) | 0.488 |
Physical complaints (7) | 2.8 (1.5) | −1.4 (0.1) | 2.8 (1.4) | −1.2 (0.1) | 0.170 |
Irritability (8) | 4.3 (1.5) | −2.3 (0.1) | 4.1 (1.5) | −1.7 (0.2) | 0.004 |
Excessive guilt (9) | 2.7 (1.5) | 1.5 (0.1) | 2.5 (1.5) | −1.2 (0.1) | 0.053 |
Low self-esteem (10) | 3.8 (1.4) | −2.1 (0.1) | 3.6 (1.3) | −1.7 (0.2) | 0.019 |
Depressed feelings (11) | 4.6 (1.1) | −2.9 (0.1) | 4.5 (1.1) | −2.4 (0.2) | 0.005 |
Morbid ideation (12) | 2.2 (1.3) | −0.8 (0.1) | 2.0 (1.3) | −0.8 (0.1) | 0.780 |
Suicidal ideation (13) | 1.3 (0.7) | −0.2 (0.1) | 1.2 (0.6) | −0.16 (0.1) | 0.430 |
Excessive weeping (14) | 2.8 (1.6) | −1.5 (0.1) | 2.5 (1.6) | −1.5 (0.1) | 0.897 |
Depressed facial affect (15) | 3.4 (1.2) | −1.9 (0.1) | 3.2 (1.2) | −1.6 (0.1) | 0.067 |
Listless speech (16) | 2.1 (0.8) | −0.9 (0.1) | 2.2 (0.9) | −1.0 (0.1) | 0.857 |
Hypoactivity (17) | 2.4 (1.1) | −1.2 (0.1) | 2.4 (1.1) | −1.0 (0.1) | 0.166 |