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Table 4 Changes in CDRS-R Item scores from baseline to week 8 (mixed-model repeated measures)

From: Quality of life in children and adolescents with bipolar I depression treated with olanzapine/fluoxetine combination

CDRS-R item (Item #) OFC, N = 170 mean baseline (SD) OFC, N = 170 LS mean change (SE) Placebo, N = 84 mean baseline (SD) Placebo, N = 84 LS mean change (SE) Between-group p value
Total 54.6 (10.0) −28.4 (1.1) 53.7 (8.2) −23.4 (1.5) 0.003
Impaired schoolwork (1) 4.1 (1.4) −1.92 (0.1) 4.0 (1.3) −1.5 (0.2) 0.019
Difficulty having fun (2) 4.5 (1.2) −2.7 (0.1) 4.7 (1.1) −2.2 (0.2) 0.023
Social withdrawal (3) 3.9 (1.2) −2.3 (0.1) 4.0 (1.2) −1.8 (0.2) 0.003
Sleep disturbance (4) 3.4 (1.3) −2.1 (0.1) 3.4 (1.3) −1.3 (0.1) <.001
Appetite disturbance (5) 2.4 (1.2) −0.5 (0.1) 2.7 (1.3) −0.8 (0.2) 0.171
Excessive fatigue (6) 4.0 (1.5) −2.3 (0.1) 3.9 (1.7) −2.2 (0.2) 0.488
Physical complaints (7) 2.8 (1.5) −1.4 (0.1) 2.8 (1.4) −1.2 (0.1) 0.170
Irritability (8) 4.3 (1.5) −2.3 (0.1) 4.1 (1.5) −1.7 (0.2) 0.004
Excessive guilt (9) 2.7 (1.5) 1.5 (0.1) 2.5 (1.5) −1.2 (0.1) 0.053
Low self-esteem (10) 3.8 (1.4) −2.1 (0.1) 3.6 (1.3) −1.7 (0.2) 0.019
Depressed feelings (11) 4.6 (1.1) −2.9 (0.1) 4.5 (1.1) −2.4 (0.2) 0.005
Morbid ideation (12) 2.2 (1.3) −0.8 (0.1) 2.0 (1.3) −0.8 (0.1) 0.780
Suicidal ideation (13) 1.3 (0.7) −0.2 (0.1) 1.2 (0.6) −0.16 (0.1) 0.430
Excessive weeping (14) 2.8 (1.6) −1.5 (0.1) 2.5 (1.6) −1.5 (0.1) 0.897
Depressed facial affect (15) 3.4 (1.2) −1.9 (0.1) 3.2 (1.2) −1.6 (0.1) 0.067
Listless speech (16) 2.1 (0.8) −0.9 (0.1) 2.2 (0.9) −1.0 (0.1) 0.857
Hypoactivity (17) 2.4 (1.1) −1.2 (0.1) 2.4 (1.1) −1.0 (0.1) 0.166
  1. CDRS-R children’s depression rating scale-revised, LS least squares, N number of patients, OFC olanzapine/fluoxetine combination, SD standard deviation, SE standard error