Child and Adolescent Psychiatry and Mental Health

Table 1 Summary of incidence of TEAEs and serious TEAEs

From: A retrospective medical chart review of clinical outcomes in children and adolescents with attention-deficit/hyperactivity disorder treated with guanfacine extended-release in routine Canadian clinical practice

Parameter	Total (N = 330)
Parameter	N of events	N of patients	% patients
Total TEAEs	349	147	44.5
Seriousness
Non-serious	341	145	43.9
Serious^a	8	7	2.1
Severity
Mild	314	132	40.0
Moderate	29	23	7.0
Severe	6	5	1.5
Relationship to study drug
Related	263	126	38.2
Not related	86	55	16.7
Action taken
No action taken	185	92	27.9
Dose reduced	60	37	11.2
Dose increased	50	33	10.0
Dose interrupted	6	4	1.2
Treatment discontinued	48	32	9.7
Outcome
Resolved	299	133	40.3
Resolved with sequelae	0	0	0.0
Resolving	19	16	4.8
Not resolved	22	18	5.5
Death	0	0	0.0
Unknown	9	9	2.7

TEAE treatment-emergent adverse event
^aSerious TEAEs were hypotension (2 events), suicidal ideation (2 events), sinus bradycardia (1 event), aggression (1 event), agitation (1 event), and insomnia (1 event)

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ISSN: 1753-2000

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