Table 1 Characteristics of the population
Variables | Total ETAPE sample | Group of patients with at least one psychiatric AE | ||
|---|---|---|---|---|
All psychiatric AEs | AEs Attributable to AP | AEs Non attributable to AP | ||
N % (n) | 100% (190) | 63% (120) | 75% (95) | 25% (25) |
Age mean (± SD) | 12.1 (± 2.9) | 12.2 (± 3.1) | 12.3 (± 3.1) | 11.9 (± 2.8) |
Sex % (n) | ||||
Boys | 73.7% (140) | 70.8% (85) | 72.6% (69) | 64% (16) |
Girls | 26.3% (50) | 29.2% (35) | 27.4% (26) | 36% (9) |
Tanner status % (n) | ||||
I Prepuberty | 32.6% (62) | 33.3% (40) | 31.6% (30) | 40% (10) |
II-IV Puberty in progress | 42.7% (81) | 40% (48) | 41% (39) | 36% (9) |
V Puberty completed | 24.7% (47) | 26.6% (32) | 27.4% (26) | 24% (6) |
Clinical diagnoses (DSM) % (n) | ||||
Schizophrenia spectrum and other psychotic disorders | 27.9% (53) | 30% (36) | 29.5% (28) | 32% (8) |
Disruptive, impulse-control, and conduct disorders | 19.5% (37) | 19.2% (23) | 20% (19) | 16% (4) |
Bipolar disorders | 11% (21) | 9.2% (11) | 7.4% (7) | 16% (4) |
Autism spectrum disorder | 10.5% (20) | 10.8% (13) | 11.6% (11) | 8% (2) |
Personality disorders | 9.5% (18) | 10.8% (13) | 12.6% (12) | 4% (1) |
Anxiety disorders | 7.4% (14) | 9.2% (11) | 8.4% (8) | 12% (3) |
Eating disorders | 4.7% (9) | 4.2% (5) | 4.2% (4) | 0 |
ADHD | 3.1% (6) | 3.3% (4) | 3.1% (3) | 4% (1) |
Tourette syndrome | 2.6% (5) | 2.5% (3) | 2.1% (2) | 0 |
Fragile X syndrome | 0.5% (1) | 0.8% (1) | 1% (1) | 0 |
Others | 3.1% (6) | 0 | 0 | 0 |
CGI-S mean (± SD) | 4.83 (± 0.84) | 4.85 (± 0.92) | 4.82 (± 0.92) | 4.96 (± 0.91) |
CGAS mean (± SD) | 47 (± 10.7) | 46.2 (± 9.9) | 45.6 (± 9.3) | 48.3 (± 12) |
AP drug | ||||
Risperidone | 50.5% (96) | 52.5% (63) | 54.7% (52) | 44% (11) |
Aripiprazole | 34.2% (65) | 30.8% (37) | 25.2% (24) | 52% (13) |
Cyamemazine | 8.4% (16) | 10% (12) | 11.6% (11) | 4% (1) |
Olanzapine | 4.2% (8) | 3.3% (4) | 4.2% (4) | 0 |
Loxapine | 1.6% (3) | 2.5% (3) | 3.2% (3) | 0 |
Quetiapine | 1.1% (2) | 0.8% (1) | 1.% (1) | 0 |
AP generation | ||||
SGA | 91.6% (174) | 90% (108) | 88.4% (84) | 96% (24) |
FGA | 8.4% (16) | 10% (12) | 11.6% (11) | 4% (1) |