Table 4 Testing for the moderating role of the 5-HTR2A gene rs6313 polymorphism and gender

Covariates:

 Age

0.04

0.03

1.48

[−0.01, 0.10]

−0.01

0.04

-0.20

[−0.08, 0.06]

 SE

−0.48

0.03

−15.45

[−0.54, −0.42]

0.06

0.04

1.39

[−0.26, 0.15]

Study variables:

 Gender

−0.17

0.06

−2.88**

[−0.29, −0.06]

−0.11

0.07

−1.42

[−0.25, 0.04]

 PV

0.32

0.03

10.20***

[0.26, 0.39]

0.16

0.04

3.95***

[0.08, 0.25]

 Rs6313

−0.09

0.06

−1.47

[−0.21, 0.03]

−0.03

0.08

−0.36

[−0.18, 0.12]

 PV × rs6313

−0.12

0.06

−1.96

[−0.24, 0.00]

0.02

0.09

0.29

[−0.14, 0.19]

 PV × Gender

−0.04

0.06

−0.69

[−0.16, 0.08]

−0.11

0.09

−1.26

[−0.28, 0.06]

 rs6313 × Gender

0.13

0.12

1.06

[−0.11, 0.37]

0.08

0.15

0.55

[−0.21, 0.38]

 PV × rs6313 × Gender

0.38

0.13

3.04**

[0.14, 0.63]

−0.04

0.18

−0.26

[−0.39, 0.30]

 Depression

–

–

–

–

0.25

0.05

5.23***

[0.16, 0.35]

 Depression × rs6313

–

–

–

–

−0.14

0.08

−1.73

[−0.31, 0.02]

 Depression × Gender

–

–

–

–

−0.10

0.08

−1.26

[−0.27, 0.06]

 Depression × rs6313 × Gender

–

–

–

–

0.38

0.17

2.30*

[0.06, 0.71]

R²

0.42

0.14

F

54.47***

7.96***