Child and Adolescent Psychiatry and Mental Health

Table 11 Summary of directions of associations with ADHD-risk alleles

From: Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain

Phenotype	ADHD-risk	mRNA		TIV	Subcortical GMV				Cortical GMV
Class					Basal ganglia		Limbic system		Cortex	Limbic system
Regions							HIPP	AMYL
Cohorts		BRAINEAC	GTEx	ENIGMA2	ENIGMA2	ABCD	ENIGMA2	ABCD	ABCD	ABCD
↑: increase	X				X	X	X		F,P,T,O,C	PCC
↓: decrease		X	X	X				X	F,T,C

TIV, total intracranial volume; GMV, gray matter volume; HIPP, hippocampus; AMYL, amygdala
F, frontal; P, parietal; T, temporal; O, occipital; C, cerebellar; PCC, posterior cingulate cortex

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ISSN: 1753-2000

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