Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain

Table 9 p values for rs17090738-ADHD (in males), SNP-mRNA and SNP-subcortical GMV associations

“SNP-ADHD” association				“SNP-mRNA” association					“SNP-subcortical GMV” association
Risk allele	Discovery sample (ABCD)	Replication sample (PUWMa)	Replication sample (META_PGC_iPSYCH)	Effective allele	GTEx	BRAINEAC	GTEx	BRAINEAC	Effective allele	M + F "UR"	M + F "UR"	Effective allele	M ABCD
					Cortex		Basal	Limbic		Basal ganglia			Limbic system
					Frontal	Occipital	NAc	THAL		NAc	Pallidum		Left amygdala
G	0.024	0.015	0.003	A	0.011	0.003	-	0.039	G	0.022	0.032	A	0.030

Risk allele is a minor allele (f < 0.5)
M, male; F, female; “UR”, “unrestricted” cohort; NAc, nucleus accumbens; GMV, gray matter volume

ISSN: 1753-2000