Change during assessment | Change during standard treatment | Change during extended treatment | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phase 1: t0-t1 | Phase 2 and 3: t1-t3 | Phase 3a: t3-t5 | Phase 3b: t5-t7 | Phase 3c: t7-t9 | Phase 3d: t9-t10 | ||||||||
Outcome | n | β (CI 95%) | ES | β (CI 95%) | ES | β (CI 95%) | ES | β (CI 95%) | ES | β (CI 95%) | ES | β (CI 95%) | ES |
CY-BOCS-D rating scale | |||||||||||||
38 | − 0.34a (− 0.69 to 0.01) | − 0.48 | − 0.54***b,c (− 0.72 to − 0.36) | − 1.53 | − 0.42***a,c (− 0.61 to − 0.24) | − 1.19 | − 0.05b,d (− 0.25 to 0.16) | − 0.14 | − 0.08b,d (− 0.33 to 0.16) | − 0.23 | − 0.06a,c (− 0.62 to 0.49) | − 0.09 | |
Obsession severity | 38 | − 0.18a (− 0.40 to 0.04) | − 0.25 | − 0.23***a,c (− 0.35 to − 0.12) | − 0.66 | − 0.17**a,c (− 0.28 to − 0.05) | − 0.47 | − 0.07a,d (− 0.19 to 0.06) | − 0.18 | 0.01b,d (− 0.14 to 0.16) | 0.03 | − 0.13a,c (− 0.47 to 0.21) | − 0.18 |
Compulsion severity | 38 | − 0.18*a (− 0.36 to − 0.00) | − 0.49 | − 0.29***b,c (− 0.38 to − 0.20) | − 1.56 | − 0.22***a,c (− 0.32 to − 0.13) | − 1.21 | 0.01b,d (− 0.09 to 0.11) | 0.05 | − 0.06b,d (− 0.18 to 0.07) | − 0.31 | − 0.05a,c (− 0.32 to 0.23) | − 0.12 |
OCD-CA | |||||||||||||
Total OCD symptoms | [31] | [− 0.32a] [(− 1.20 to 0.56)] | [− 0.11] | [− 0.53*a,c] [(− 0.97 to − 0.10)] | [− 0.38] | [− 0.65**a,c] [(− 1.09 to − 0.21)] | [− 0.46] | [− 0.42a,c] [(− 0.91 to 0.06)] | [− 0.30] | [− 0.03a,c] [(− 0.59 to 0.53)] | [− 0.02] | [0.70a,c] [(− 0.61 to 2.01)] | [0.25] |
{37} | {− 0.72a} {(− 1.48 to 0.04)} | {− 0.25} | {− 0.56**a,c} {(− 0.96 to − 0.16)} | {− 0.40} | {− 0.73***a,c} {(− 1.13 to − 0.32)} | {− 0.51} | {− 0.03b,d} {(− 0.48 to 0.43)} | {− 0.02} | {− 0.09b,c} {(− 0.62 to 0.45)} | {− 0.06} | {0.25a,c} {(− 0.98 to 1.49)} | {0.09} | |
OCD-related problem list | |||||||||||||
Frequency | [31] | [− 0.04*a] [(− 0.08 to − 0.00)] | [− 0.23] | [− 0.05***a,c] [(− 0.06 to − 0.04)] | [− 0.57] | [− 0.04***a,c] [(− 0.05 to − 0.03)] | [− 0.47] | [− 0.02***b,d] [(− 0.03 to − 0.01)] | [− 0.25] | [− 0.01b,d] [(− 0.03 to 0.00)] | [− 0.17] | [0.06**b,d] [(0.02 to 0.10)] | [0.36] |
{32} | {− 0.01a} {(− 0.05 to 0.04)} | {− 0.04} | {− 0.06***b,c} {(− 0.08 to − 0.04)} | {− 0.90} | {− 0.04***b,d} {(− 0.06 to − 0.02)} | {− 0.62} | {0.00a,d} {(− 0.02 to 0.02)} | {− 0.05} | {− 0.01a,d} {(− 0.03 to 0.01)} | {− 0.16} | {− 0.02a,c} {(− 0.08 to 0.05)} | {− 0.14} | |
Strain | [31] | [− 0.12**a] [(− 0.21 to − 0.03)] | [− 0.39] | [− 0.07***b,c] [(− 0.10 to − 0.04)] | [− 0.46] | [− 0.11***a,d] [(− 0.14 to − 0.09)] | [− 0.73] | [− 0.04**b,c] [(− 0.07 to − 0.01)] | [− 0.28] | [− 0.01b,d] [(− 0.05 to 0.02)] | [− 0.09] | [0.01b,d] [(− 0.05 to 0.16)] | [0.18] |
{32} | {− 0.13*a} {(− 0.25 to − 0.01)} | {− 0.49} | {− 0.11***a,c} {(− 0.15 to − 0.06)} | {− 0.81} | {− 0.10***a,c} {(− 0.14 to − 0.06)} | {− 0.77} | {0.00b,d} {(− 0.04 to 0.05)} | {0.04} | {− 0.03b,d} {(− 0.09 to 0.03)} | {− 0.25} | {0.09b,d} {(− 0.07 to 0.25)} | {0.34} | |
Psychosocial impairment | [30] | [− 0.06***a] [(− 0.10 to − 0.03)] | [− 0.36] | [− 0.03***b,c] [(− 0.04 to − 0.02)] | [− 0.36] | [− 0.02***b,c] [(− 0.03 to − 0.01)] | [− 0.25] | [− 0.01b,d] [(− 0.02 to 0.01)] | [− 0.06] | [0.00b,d] [(− 0.01 to 0.01)] | [0.00] | [0.00b,c] [(− 0.03 to 0.04)] | [0.03] |
{36} | {− 0.03a} {(− 0.07 to 0.01)} | {− 0.26} | {− 0.05***b,c} {(− 0.07 to − 0.04)} | {− 0.82} | {− 0.02*b,d} {(− 0.03 to − 0.00)} | {− 0.28} | {0.00b,d} {(− 0.02 to 0.02)} | {0.05} | {0.00b,d} {(− 0.02 to 0.03)} | {0.04} | {− 0.04a,c} {(− 0.10 to 0.02)} | {− 0.29} | |
OCD-functional impairment list | |||||||||||||
Total psychosocial impairment | [30] | [− 1.35***a] [(− 1.64 to − 1.05)] | [− 0.57] | [− 0.36***b,c] [(− 0.46 to − 0.27)] | [− 0.31] | [− 0.26***b,d] [(− 0.35 to − 0.18)] | [− 0.22] | [− 0.10*b,d] [(− 0.19 to − 0.01)] | [− 0.09] | [− 0.17**b,d] [(− 0.28 to − 0.05)] | [− 0.14] | [0.27b,d] [(− 0.08 to 0.61] | [0.11] |
{35} | {− 1.52***a} {(− 2.01 to − 1.03)} | {− 0.80} | {− 0.56***b,c} {(− 0.75 to − 0.37)} | {− 0.59} | {− 0.19*b,d} {(− 0.38 to 0.00)} | {− 0.20} | {− 0.03b,d} {(− 0.25 to 0.18)} | {− 0.04} | {− 0.43**b,c} {(− 0.70 to − 0.16)} | {− 0.45} | {0.13b,c} {(− 0.60 to 0.86)} | {0.07} |