Time course of PERMP-A (closed symbols) and PERMP-C (open symbols) assessment over the laboratory school day. LS mean (SE) actual scores (top) and change from predose (bottom) for LDX (squares) and placebo (circles) at predose (-0.5 h) and at 1.5, 2.5, 5, 7.5, 10, 12, and 13 h postdose. Scores were compared using a linear mixed model with sequence, period, and treatment as fixed effects and subject within sequence as a random effect. Higher scores denote improvement. *Denotes P < .0001 LDX compared with placebo for PERMP-A. †Denotes P < .0001 LDX compared with placebo for PERMP-C.