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Table 3 Demographic and baseline data of the pooled sample

From: Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials

 

Placebo-controlled studies

All studies

Characteristics

Children

(N = 275)

Adolescents

(N = 112)

p-value

Children

(N = 611)

Adolescents

(N = 183)

p-value

Gender

  

0.45

  

0.152

   Female (n, %)

44 (16.0)

16 (14.3)

 

115 (18.8)

21 (11.5)

 

   Male (n, %)

231 (84.0)

96 (85.7)

 

496 (81.2)

162 (88.5)

 

Age, mean (SD), y

8.7 (1.53)

13.0 (1.04)

NA

8.7 (1.51)

13.0 (0.99)

NA

ADHD subtype

  

0.002

  

<0.001

   Combined (n, %)

223 (81.1)

72 (64.3)

 

508 (83.1)

133 (72.7)

 

   Hyperactive/impulsive (n, %)

10 (3.6)

7 (6.3)

 

14 (2.3)

10 (5.5)

 

   Inattentive (n, %)

42 (15.3)

33 (29.5)

 

89 (14.6)

40 (21.9)

 

ADHD-RS, mean (SD)

      

   Total score

41.4 (7.42)

38.4 (7.83)

0.002

42.1 (7.87)

41.0 (8.57)

0.004

   Inattentive subscore

21.6 (3.70)

21.9 (3.85)

0.35

22.1 (3.80)

22.5 (3.90)

0.374

   Hyperactive/impulsive subscore

19.8 (5.51)

16.5 (6.53)

<0.001

20.0 (5.79)

18.4 (6.67)

<0.001

  1. p-value based on two-way analysis of variance (ANOVA) including terms age and study for continuous variables and based on Cochran-Mantel-Haenszel test controlling for study for categorical variables
  2. Abbreviations: SD, standard deviation; ADHD, attention deficit/hyperactivity disorder; ADHD-RS, Attention Deficit/Hyperactivity Disorder Rating Scale; NA, Not Applicable