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Table 4 Child Health and Illness Profile-Child Edition, baseline data

From: Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials

  Placebo controlled studies All studies
CHIP-CE items Children (N = 275) Adolescents (N = 112) p-value Children (N = 611) Adolescents (N = 183) p-value
CHIP-CE       
   Total Score 31.9 (10.87) 29.3 (11.80) 0.030 29.3 (11.58) 27.5 (12.29) 0.296
   Satisfaction Domain 36.3 (13.66) 32.9 (14.20) 0.031 34.9 (13.88) 32.9 (14.49) 0.066
   Satisfaction with Health 43.0 (12.89) 40.8 (14.13) 0.294 40.9 (13.22) 40.6 (14.45) 0.388
   Satisfaction with Self 32.4 (13.99) 28.6 (13.88) 0.004 32.3 (14.34) 29.0 (14.21) 0.018
   Comfort Domain 46.0 (9.92) 46.2 (10.35) 0.526 43.3 (10.75) 44.7 (11.00) 0.426
   Physical Comfort 52.0 (9.32) 52.7 (9.80) 0.423 50.7 (9.84) 52.0 (10.18) 0.850
   Emotional Comfort 41.0 (10.96) 42.0 (10.76) 0.162 37.7 (11.80) 39.9 (11.59) 0.029
   Restricted Activity 50.5 (10.13) 47.4 (11.07) 0.022 50.2 (10.02) 48.1 (10.89) 0.027
   Risk Avoidance Domain 33.7 (12.11) 32.8 (12.54) 0.396 30.6 (14.75) 29.0 (14.18) 0.378
   Individual Risk Avoidance 39.1 (13.15) 40.9 (12.83) 0.213 35.6 (15.71) 35.8 (15.28) 0.004
   Threats to Achievement 33.8 (11.80) 31.8 (12.39) 0.064 31.4 (13.67) 29.2 (13.27) 0.719
   Resilience Domain 36.2 (11.98) 35.2 (11.20) 0.197 36.5 (11.91) 34.5 (12.33) 0.096
   Family Involvement 40.6 (10.84) 36.7 (10.74) <0.001 41.4 (11.26) 36.3 (12.24) <0.001
   Physical Activity 44.4 (11.20) 45.2 (11.04) 0.952 46.4 (11.73) 46.5 (11.94) 0.373
   Social Problem Solving 36.9 (12.58) 38.2 (12.36) 0.452 35.1 (13.01) 35.8 (12.85) 0.112
   Achievement Domain 33.4 (9.92) 29.2 (10.50) <0.001 31.0 (10.26) 28.9 (10.71) 0.046
   Academic Performance 32.8 (9.47) 27.9 (8.80) <0.001 32.0 (9.91) 27.7 (9.38) <0.001
   Peer Relations 39.7 (13.35) 38.6 (14.40) 0.703 36.7 (13.19) 38.4 (14.12) 0.051
  1. Data is presented as unadjusted mean and SD (if not otherwise indicated)
  2. p-value is based on two-way analysis of variance (ANOVA) including terms age and study
  3. Abbreviations: CHIP-CE, Child Health and Illness Profile, Child Edition; SD, standard deviation
  4. Significant p-values are bolded