Efficacy and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: sex and age effects and effect size across the day

Table 4 LS Mean (SE) Postdose SKAMP and PERMP Effect Sizes*

Hour	SKAMP-D LS Mean (SE) Effect Size	SKAMP-A LS Mean (SE) Effect Size	SKAMP Quality of Work LS Mean (SE) Effect Size	SKAMP Total LS Mean (SE) Effect Size	PERMP-A LS Mean (SE) Effect Size	PERMP-C LS Mean (SE) Effect Size
1.5	-0.68 (0.14)	-0.57 (0.14)	-0.23 (0.13)	-0.85 (0.15)	0.59 (0.14)	0.74 (0.14)
2.5	-1.41 (0.16)	-1.20 (0.16)	-1.05 (0.15)	-1.89 (0.18)	1.28 (0.16)	1.34 (0.16)
5.0	-1.44 (0.16)	-1.19 (0.16)	-1.24 (0.16)	-1.90 (0.18)	1.40 (0.16)	1.44 (0.16)
7.5	-1.41 (0.16)	-1.27 (0.16)	-1.17 (0.16)	-1.94 (0.19)	1.53 (0.17)	1.56 (0.17)
10.0	-1.12 (0.15)	-1.11 (0.15)	-0.77 (0.14)	-1.64 (0.17)	1.39 (0.16)	1.44 (0.16)
12.0	-0.78 (0.14)	-0.89 (0.15)	-0.75 (0.14)	-1.35 (0.16)	1.15 (0.15)	1.21 (0.16)
13.0	-0.38 (0.14)	-0.80 (0.14)	-0.44 (0.14)	-0.84 (0.14)	1.10 (0.15)	1.11 (0.15)
Mean^†	-1.73 (0.18)	-1.54 (0.17)	-1.73 (0.18)	-2.41 (0.21)	1.78 (0.18)	1.83 (0.18)

LS: least squares; PERMP: Permanent Product Measure of Performance; PERMP-A: PERMP-Attempted; PERMP-C: PERMP-Correct; SE: standard error; SKAMP: Swanson, Kotkin, Agler, M-Flynn, and Pelham; SKAMP-A: SKAMP-Attention; SKAMP-D: SKAMP-Deportment.
*Negative SKAMP effect sizes indicate improvement with LDX. Positive PERMP effect sizes indicate improvement with LDX.
^†Mean SKAMP and PERMP scores across the day were calculated employing the model-based calculations using all measures for all participants at all time points across the day.

ISSN: 1753-2000