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Table 3 Health-related quality of life (TACQoL) 1 : patients with congenital hypothyroidism (CH) versus the norm population; Mean scores, Standard deviations (SD’s) and effect sizes 2

From: Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening

  Total CH Severe CH Moderate/Mild CH Norm population Effect size
  Mean (SD) Mean (SD) Mean (SD) Mean (SD) Total
Child-report      
  n = 82 n = 41 n = 41 n = 449  
Physical Functioning 23.7 (4.8) 23.3 (4.9) 24.0 (4.6) 25.2 (5.0) 0.3
Motor Functioning 28.3 (3.5) *** 27.9 (3.8) *** 28.7 (3.3) * 29.8 (3.1) 0.5
Autonomy 30.9 (1.5) 30.5 (1.7) ** 31.3 (1.1) 31.5 (1.5) 0.4
Cognitive functioning 26.5 (4.9) *** 25.3 (5.1) *** 27.7 (4.4) 28.7 (3.7) 0.6
Social Functioning 28.6 (4.0) *** 28.0 (4.2) *** 29.1 (3.9) 29.9 (2.5) 0.5
Positive emotions 12.6 (2.6) *** 13.0 (2.4) 12.2 (2.8) *** 13.7 (2.4) 0.5
Negative emotions 12.0 (2.5) 11.4 (2.6) 12.5 (2.3) 11.9 (2.6) 0.0
Parent-report      
  n = 82 n = 41 n = 41 n = 465  
Physical Functioning 26.9 (4.4) 26.5 (4.3) 27.3 (4.3) 27.3 (3.8) 0.1
Motor Functioning 29.3 (2.8) *** 28.7 (3.2) *** 30.0 (2.3) 30.8 (2.3) 0.7
Autonomy 31.2 (1.9) 31.1 (1.9) 31.2 (2.0) 31.6 (1.2) 0.3
Cognitive functioning 26.0 (5.2) *** 25.1 (5.7) *** 26.9 (4.5) ** 29.0 (3.7) 0.8
Social Functioning 29.0 (3.1) ** 28.9 (3.0) 29.1 (3.3) 29.9 (2.5) 0.4
Positive emotions 14.5 (2.1) 14.4 (2.3) 14.7 (2.0) 14.7 (2.0) 0.1
Negative emotions 11.0 (2.4) ** 10.9 (1.8) 11.2 (2.8) 11.8 (2.4) 0.3
  1. 1Higher scores represent better HRQoL: range 0 – 32 for physical, motor, autonomy, cognitive, social; range 0 – 16 for positive and negative moods.
  2. 2effect size (d): total CH versus norm population.
  3. *p < 0.007: difference between CH patients and norm population according to ANOVA by group and gender.
  4. **p < 0.001: difference between CH patients and norm population according to ANOVA by group and gender.
  5. ***p < 0.0001: difference between CH patients and norm population according to ANOVA by group and gender.