Table 3 Health-related quality of life (TACQoL) ¹ : patients with congenital hypothyroidism (CH) versus the norm population; Mean scores, Standard deviations (SD’s) and effect sizes ²

Child-report

n = 82

n = 41

n = 41

n = 449

Physical Functioning

23.7 (4.8)

23.3 (4.9)

24.0 (4.6)

25.2 (5.0)

0.3

Motor Functioning

28.3 (3.5) ***

27.9 (3.8) ***

28.7 (3.3) *

29.8 (3.1)

0.5

Autonomy

30.9 (1.5)

30.5 (1.7) **

31.3 (1.1)

31.5 (1.5)

0.4

Cognitive functioning

26.5 (4.9) ***

25.3 (5.1) ***

27.7 (4.4)

28.7 (3.7)

0.6

Social Functioning

28.6 (4.0) ***

28.0 (4.2) ***

29.1 (3.9)

29.9 (2.5)

0.5

Positive emotions

12.6 (2.6) ***

13.0 (2.4)

12.2 (2.8) ***

13.7 (2.4)

0.5

Negative emotions

12.0 (2.5)

11.4 (2.6)

12.5 (2.3)

11.9 (2.6)

0.0

Parent-report

n = 82

n = 41

n = 41

n = 465

Physical Functioning

26.9 (4.4)

26.5 (4.3)

27.3 (4.3)

27.3 (3.8)

0.1

Motor Functioning

29.3 (2.8) ***

28.7 (3.2) ***

30.0 (2.3)

30.8 (2.3)

0.7

Autonomy

31.2 (1.9)

31.1 (1.9)

31.2 (2.0)

31.6 (1.2)

0.3

Cognitive functioning

26.0 (5.2) ***

25.1 (5.7) ***

26.9 (4.5) **

29.0 (3.7)

0.8

Social Functioning

29.0 (3.1) **

28.9 (3.0)

29.1 (3.3)

29.9 (2.5)

0.4

Positive emotions

14.5 (2.1)

14.4 (2.3)

14.7 (2.0)

14.7 (2.0)

0.1

Negative emotions

11.0 (2.4) **

10.9 (1.8)

11.2 (2.8)

11.8 (2.4)

0.3