Child and Adolescent Psychiatry and Mental Health

Table 2 Subgroup analyses of O3FA for the treatment of depressive disorders in children and adolescents

From: Omega-3 fatty acids for the treatment of depressive disorders in children and adolescents: a meta-analysis of randomized placebo-controlled trials

Subgroups	Overall effect		Subgroup difference
Subgroups	SMD (95% CI)	P	I² (%)	P
Mean age (years)^a
≤ 12 [27, 29]	− 0.45 (− 1.43, 0.53)	0.37	0	0.34
> 12 [28, 30]	0.07 (− 0.36, 0.51)	0.74	0	0.34
Severity of depression
Mild [27]	− 0.00 (− 0.96, 0.67)	1.00	0	0.67
Moderate to severe [28,29,30]	− 0.19 (− 0.79, 0.40)	0.52	0	0.67
Daily dosage of EPA (g/day)
≤ 1 [29, 30]	− 0.44 (− 1.44, 0.56)	0.39	0	0.36
> 1 [27, 28]	0.07 (− 0.37, 0.50)	0.76	0	0.36

EPA eicosapentaenoic acid
^aChildren were aged between 6 and 12 years and adolescents were aged between 13 and 18 years

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ISSN: 1753-2000

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