Table 4 Factors associated with missed doses in the past month among HIV-infected children on ART in southwestern China
Variables | N | Missed doses in the past month, N (%) | OR (95% CI) | P-value | AOR (95% CI) | P-value |
|---|---|---|---|---|---|---|
Total | 325 | 90 (27.7) | Â | Â | Â | Â |
Age at study survey (years) | ||||||
 11–13 | 142 | 36 (25.4) | 1.00 |  |  |  |
 14–17 | 183 | 54 (29.5) | 1.23 (0.75–2.02) | 0.407 |  |  |
Sex | ||||||
 Female | 156 | 38 (24.4) | 1.00 |  |  |  |
 Male | 169 | 52 (30.8) | 1.38 (0.85–2.25) | 0.198 |  |  |
Route of HIV infection | ||||||
 Mother-to-child transmission | 312 | 88 (28.2) | 1.00 |  |  |  |
 Others | 13 | 2 (15.4) | 0.46 (0.10–2.13) | 0.323 |  |  |
WHO clinical stage before ART | ||||||
 I/II | 228 | 60 (26.3) | 1.00 |  |  |  |
 III/IV | 97 | 30 (30.9) | 1.25 (0.74–2.11) | 0.396 |  |  |
CD4 cell count before ART (cells/mm3) | ||||||
 ≥ 200 | 224 | 58 (25.9) | 1.00 |  |  |  |
 < 200 | 101 | 32 (31.7) | 1.33 (0.79–2.22) | 0.281 |  |  |
Age at ART initiation (years) | ||||||
 < 5 | 172 | 45 (26.2) | 1.00 |  |  |  |
 ≥ 5 | 153 | 45 (29.4) | 1.18 (0.72–1.91) | 0.514 |  |  |
Year of ART initiation | ||||||
 < 2012 | 144 | 35 (24.3) | 1.00 |  |  |  |
 ≥ 2012 | 181 | 55 (30.4) | 1.36 (0.83–2.23) | 0.224 |  |  |
Initial ART regimen | ||||||
 The first-line ART | 212 | 65 (30.7) | 1.00 |  |  |  |
 The second-line ART | 113 | 25 (22.1) | 0.64 (0.38–1.09) | 0.103 |  |  |
Time on ART (years) | ||||||
 < 10 | 192 | 58 (30.2) | 1.00 |  |  |  |
 ≥ 10 | 133 | 32 (24.1) | 0.73 (0.44–1.21) | 0.224 |  |  |
Total difficulties score | ||||||
 Normal | 225 | 52 (23.1) | 1.00 |  | 1.00 |  |
 Borderline | 45 | 16 (35.6) | 1.84 (0.93–3.64) | 0.082 | 1.82 (0.91–3.63) | 0.091 |
 Abnormal | 55 | 22 (40.0) | 2.22 (1.19–4.13) | 0.012 | 2.06 (1.10–3.88) | 0.024 |
Physical functioning score | ||||||
 ≥ 80 | 229 | 56 (24.5) | 1.00 |  |  |  |
 < 80 | 96 | 34 (35.4) | 1.69 (1.01–2.84) | 0.045 |  |  |
General health score | ||||||
 ≥ 80 | 166 | 40 (24.1) | 1.00 |  |  |  |
 < 80 | 159 | 50 (31.4) | 1.45 (0.89–2.36) | 0.140 |  |  |
Frequency of having received assistance and support from parents over the past 3Â months | ||||||
 Often or always | 161 | 34 (21.1) | 1.00 |  | 1.00 |  |
 Never, occasionally or sometimes | 164 | 56 (34.1) | 1.94 (1.18–3.18) | 0.009 | 1.85 (1.12–3.06) | 0.017 |
Frequency of having received assistance and support from other sources over the past 3Â months | Â | |||||
 Often or always | 245 | 70 (28.6) | 1.00 |  |  |  |
 Never, occasionally, or sometimes | 80 | 20 (25.3) | 0.83 (0.47–1.48) | 0.536 |  |  |