Skip to main content

Table 2 Propensity score weighted hazard ratios (95% CI) of emotional outcomes in children according to maternal exposure to SSRI (N06AB) in utero (1997–2015)

From: Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study

OUTCOME

Exposure

Person Yrs

Events

HR (95% CI)

 

Any diagnosis or medication

No

8,699,120

33,367

1.00 (ref.)

 
 

Yes

130,074

856

1.55 (1.44–1.67)

 

Diagnoses

     

 Any depressive disorder1

No

8,804,271

5,980

1.00 (ref.)

 
 

Yes

132,774

121

1.55 (1.28–1.87)

 

 Any anxiety disorder 2

No

8,789,611

9,466

1.00 (ref.)

 
 

Yes

132,421

225

1.57 (1.36–1.80)

 

 Adjustment disorder 3

No

8,756,212

18,555

1.00 (ref.)

 
 

Yes

131,662

438

1.28 (1.16–1.42)

 

 Any diagnosis

No

8,711,814

29,831

1.00 (ref.)

 
 

Yes

130,377

771

1.50 (1.39–1.62)

 

Medications

     

 Any SSRI4

No

8,797,801

8,202

1.00 (ref.)

 
 

Yes

132,506

217

2.18 (1.89–2.52)

 

 Any TCA5

No

8,816,506

1,341

1.00 (ref.)

 
 

Yes

133,111

22

1.22 (0.78–1.90)

 

 Other antidepressants 6

No

8,818,418

1,662

1.00 (ref.)

 
 

Yes

133,097

33

1.67 (1.16–2.39)

 

 Any medication

No

8,791,357

10,116

1.00 (ref.)

 
 

Yes

132,422

245

1.96 (1.71–2.24)

 
  1. 1 ICD10 F32-39; 2 ICD10 F40-42; 3 ICD10 F43-49; 4 ICD10 F32-49; 5ATC N06AB; 6 ATC N06AA; 7ATC N06AX + N06AF + N06AG
  2. HR = Propensity score weighted hazard ratio; Ref: Reference (unexposed) group. TCA: tricyclic antidepressant
  3. Significant associations are bolded