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Table 3 Propensity score weighted hazard ratios (95% CI) of emotional outcomes in children according to maternal exposure to SSRI (N06AB) in women with a psychiatric diagnosis within one year prior to pregnancy (ICD10 F00-F99) (1997–2015)

From: Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study

OUTCOME

Exposure

Person Yrs

Events

HR (95% CI)

 

Any diagnosis or medication

No

91,489

505

1.00 (ref.)

 
 

Yes

47,831

318

1.38 (1.17–1.63)

 

Diagnoses

     

 Any depressive disorder1

No

93,125

84

1.00 (ref.)

 
 

Yes

48,825

48

1.59 (1.04–2.42)

 

 Any anxiety disorder 2

No

92,939

129

1.00 (ref.)

 
 

Yes

48,661

77

1.25 (0.89–1.75)

 

 Adjustment disorder 3

No

92,298

296

1.00 (ref.)

 
 

Yes

48,367

181

1.37 (1.11–1.68)

 

 Any diagnosis

No

91,662

458

1.00 (ref.)

 
 

Yes

47,904

295

1.36 (1.14–1.61)

 

Medications

     

 Any SSRI4

No

93,058

105

1.00 (ref.)

 
 

Yes

48,756

65

2.10 (1.48–2.99)

 

 Any TCA5

No

93,287

10

1.00 (ref.)

 
 

Yes

48,920

9

2.20 (0.86–5.65)

 

 Other antidepressants 6

No

93,294

26

1.00 (ref.)

 
 

Yes

48,929

5

0.89 (0.31–2.56)

 

 Any medication

No

92,978

131

1.00 (ref.)

 
 

Yes

48,728

73

1.86 (1.35–2.56)

 
  1. 1 ICD10 F32-39; 2 ICD10 F40-42; 3 ICD10 F43-49; 4 ICD10 F32-49; 5ATC N06AB; 6 ATC N06AA; 7ATC N06AX + N06AF + N06AG
  2. HR = Propensity score weighted hazard ratio; Ref: Reference (unexposed) group. TCA: tricyclic antidepressant
  3. Significant associations are bolded