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Table 4 Propensity score weighted hazard ratios (95% CI) of emotional outcomes in children according to maternal exposure to SSRI (N06AB) compared to discontinued use (1997–2015)

From: Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study

OUTCOME

Exposure

Person Yrs

Events

HR (95% CI)

 

Any diagnosis or medication

No

251,070

1,404

1.00 (ref.)

 
 

Yes

171,781

1,107

1.23 (1.13–1.34)

 

Diagnoses

     

 Any depressive disorder1

No

255,495

217

1.00 (ref.)

 
 

Yes

175,331

155

1.22 (0.98–1.51)

 

 Any anxiety disorder 2

No

254,898

365

1.00 (ref.)

 
 

Yes

174,841

283

1.21 (1.03–1.42)

 

 Adjustment disorder 3

No

253,529

785

1.00 (ref.)

 
 

Yes

173,837

584

1.14 (1.02–1.27)

 

 Any diagnosis

No

251,540

1,271

1.00 (ref.)

 
 

Yes

172,183

1,001

1.21 (1.11–1.31)

 

Medications

     

 Any SSRI4

No

255,076

329

1.00 (ref.)

 
 

Yes

174,989

265

1.49 (1.26–1.76)

 

 Any TCA5

No

255,990

45

1.00 (ref.)

 
 

Yes

175,711

28

1.04 (0.64–1.69)

 

 Other antidepressants 6

No

255,993

67

1.00 (ref.)

 
 

Yes

175,713

35

1.06 (0.70–1.61)

 

 Any medication

No

254,891

397

1.00 (ref.)

 
 

Yes

174,863

300

1.39 (1.19–1.62)

 
  1. 1 ICD10 F32-39; 2 ICD10 F40-42; 3 ICD10 F43-49; 4 ICD10 F32-49; 5ATC N06AB; 6 ATC N06AA; 7ATC N06AX + N06AF + N06AG
  2. HR = Propensity score weighted hazard ratio; Ref: Reference (unexposed) group. TCA: tricyclic antidepressant
  3. Significant associations are bolded