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Table 3 Characteristics of Treatment Effectiveness and its Effect on Adherence

From: Adherence to treatment and parents’ perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances

Reported effect a

 

N (%)

Univariate HR for treatment cessation

95% CI

p value

Multivariate HR for treatment cessation

95% CI

p-value

Effect on sleep quality

Sleep onset

67 (86%)

0.535

0.199–1.435

0.214

1.055

0.333–3.343

0.928

Sleep duration

42 (54%)

0.376

0.161–0.878

0.024

1.230

0.411–3.686

0.711

Night awakening

35 (45%)

0.208

0.071–0.610

0.004

0.142

0.036–0.565

0.006

Effect on daily behavior

Educational functioning

22 (28%)

0.271

0.080–0.913

0.035

0.195

0.047–0.806

0.024

Mood

16 (21%)

0.468

0.139–1.573

0.220

0.191

0.005–7.344

0.374

Temper tantrums

8 (10%)

0.290

0.039–2.152

0.226

2.212

0.058–83.932

0.669

Communication

7 (9%)

0.412

0.056–3.050

0.385

2.764

0.249–30.628

0.407

Sensory regulation

5 (6%)

1.093

0.256–4.655

0.905

4.119

0.119-142.282

0.434

  1. Note: a at least some effect