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Table 1 Annual percent prevalence of antipsychotic drug use in cohorts from five countries between 2005/6–2012 among children and adolescents in 4 age group

From: A multi-national comparison of antipsychotic drug use in children and adolescents, 2005–2012

  2005 2006 2007 2008 2009 2010 2011 2012 Difference 2005–2012
Denmark
 0–4 years 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.00] N/A
 5–9 years 0.07 [0.06–0.08] 0.08 [0.07–0.09] 0.09 [0.08–0.10] 0.10 [0.09–0.11] 0.12 [0.11–0.13] 0.12 [0.11–0.14] 0.11 [0.10–0.13] 0.10 [0.09–0.12] 44.9%
 10–14 years 0.26 [0.24–0.28] 0.27 [0.26–0.29] 0.33 [0.31–0.35] 0.34 [0.32–0.37] 0.39 [0.36–0.41] 0.40 [0.38–0.43] 0.40 [0.38–0.42] 0.42 [0.39–0.44] 61.5%
 15–19 years 0.77 [0.73–0.80] 0.88 [0.85–0.92] 0.94 [0.90–0.97] 1.03 [0.99–1.06] 1.11 [1.08–1.15] 1.24 [1.21–1.28] 1.30 [1.26–1.34] 1.33 [1.29–1.37] 74.3%
 Total 0.26 [0.25–0.27] 0.30 [0.29–0.31] 0.33 [0.32–0.35] 0.37 [0.36–0.38] 0.41 [0.40–0.42] 0.46 [0.44–0.47] 0.47 [0.46–0.48] 0.48 [0.47–0.50] 83.9%
Germany
 0–4 years 0.15 [0.14–0.16] 0.04 [0.03–0.05] 0.02 [0.02–0.03] 0.02 [0.02–0.03] 0.02 [0.02–0.03] 0.02 [0.01–0.02] 0.02 [0.01–0.02] 0.01 [0.01–0.02] N/A
 5–9 years 0.13 [0.12–0.15] 0.13 [0.12–0.14] 0.15 [0.14–0.17] 0.17 [0.15–0.18] 0.18 [0.16–0.19] 0.17 [0.16–0.19] 0.17 [0.16–0.18] 0.17 [0.16–0.18] 25.7%
 10–14 years 0.24 [0.23–0.26] 0.27 [0.25–0.28] 0.31 [0.29–0.33] 0.34 [0.32–0.36] 0.37 [0.35–0.39] 0.42 [0.40–0.44] 0.42 [0.41–0.45] 0.43 [0.41–0.45] 76.8%
 15–19 years 0.34 [0.33–0.36] 0.34 [0.33–0.36] 0.37 [0.35–0.39] 0.41 [0.39–0.43] 0.44 [0.42–0.46] 0.51 [0.49–0.54] 0.51 [0.52–0.56] 0.54 [0.52–0.56] 57.4%
 Total 0.23 [0.22–0.23] 0.21 [0.20–0.22] 0.23 [0.23–0.24] 0.26 [0.25–0.26] 0.28 [0.27–0.29] 0.31 [0.30–0.32] 0.31 [0.31–0.33] 0.32 [0.31–0.33] 40.8%
Netherlands
 0–4 years 0.12 [0.09–0.17] 0.08 [0.06–0.12] 0.09 [0.07–0.13] 0.09 [0.07–0.13] 0.06 [0.04–0.10] 0.09 [0.06–0.13] 0.06 [0.04–0.09] 0.07 [0.05–0.11] N/A
 5–9 years 0.80 [0.71–0.91] 0.87 [0.77–0.98] 1.01 [0.91–1.12] 0.95 [0.85–1.06] 0.97 [0.87–1.08] 0.96 [0.86–1.07] 0.86 [0.77–0.97] 0.84 [0.75–0.95] 5.3%
 10–14 years 1.18 [1.06–1.30] 1.32 [1.20–1.45] 1.56 [1.43–1.70] 1.65 [1.51–1.79] 1.68 [1.55–1.83] 1.69 [1.55–1.83] 1.67 [1.53–1.81] 1.59 [1.47–1.73] 35.5%
 15–19 years 1.04 [0.94–1.16] 1.12 [1.02–1.24] 1.15 [1.04–1.26] 1.35 [1.24–1.47] 1.44 [1.33–1.57] 1.37 [1.26–1.49] 1.34 [1.23–1.47] 1.47 [1.35–1.60] 40.8%
 Total 0.78 [0.74–0.83] 0.84 [0.80–0.89] 0.95 [0.90–1.01] 1.02 [0.97–1.07] 1.02 [0.97–1.07] 1.04 [0.99–1.10] 1.01 [0.96–1.06] 1.03 [0.98–1.09] 31.7%
UK
 0–4 years 0.00 [0.00–0.01] 0.00 [0.00–0.01] 0.00 [0.00–0.00] 0.00 [0.00–0.00] 0.00 [0.00–0.00] 0.00 [0.00–0.01] 0.00 [0.00–0.00] 0.00 [0.00–0.01] N/A
 5–9 years 0.03 [0.03–0.04] 0.03 [0.03–0.04] 0.04 [0.03–0.05] 0.04 [0.03–0.05] 0.04 [0.03–0.05] 0.05 [0.04–0.06] 0.04 [0.03–0.05] 0.03 [0.02–0.04] − 16.7%
 10–14 years 0.12 [0.11–0.14] 0.13 [0.12–0.15] 0.13 [0.12–0.14] 0.14 [0.12–0.15] 0.14 [0.13–0.16] 0.14 [0.13–0.16] 0.15 [0.13–0.16] 0.16 [0.14–0.17] 27.5%
 15–19 years 0.25 [0.23–0.28] 0.27 [0.25–0.29] 0.28 [0.26–0.30] 0.26 [0.24–0.28] 0.26 [0.25–0.29] 0.31 [0.29–0.33] 0.33 [0.31–0.35] 0.31 [0.28–0.33] 20.5%
 Total 0.11 [0.10–0.11] 0.11 [0.11–0.12] 0.12 [0.11–0.12] 0.12 [0.11–0.12] 0.12 [0.11–0.13] 0.13 [0.13–0.14] 0.14 [0.13–0.15] 0.14 [0.13–0.15] 29.3%
USA
 0–4 years N/A 0.16 [0.13–0.19] 0.12 [0.10–0.15] 0.10 [0.08–0.13] 0.07 [0.05–0.09] 0.05 [0.03–0.07] 0.04 [0.03–0.07] 0.02 [0.01–0.04] N/A
 5–9 years N/A 1.31 [1.18–1.47] 1.39 [1.25–1.54] 1.17 [1.04–1.31] 1.04 [0.92–1.18] 0.82 [0.71–0.94] 0.69 [0.59–0.81] 0.56 [0.47–0.66] − 57.5%
 10–14 years N/A 2.53 [2.33–2.75] 2.59 [2.39–2.82] 2.50 [2.29–2.72] 2.50 [2.29–2.73] 2.23 [2.03–2.44] 2.31 [2.11–2.53] 1.91 [1.73–2.10] − 24.6%
 15–19 years N/A 2.41 [2.14–2.71] 2.75 [2.47–3.06] 2.87 [2.59–3.19] 3.07 [2.77–3.41] 2.80 [2.50–3.13] 2.69 [2.41–3.01] 2.53 [2.26–2.83] 5.0%
 Total N/A 0.94 [0.89–0.99] 0.97 [0.92–1.03] 0.93 [0.88–0.98] 0.96 [0.91–1.02] 0.88 [0.82–0.94] 0.90 [0.85–0.96] 0.79 [0.74–0.85] − 15.6%
  1. Numbers in brackets = 95% confidence interval
  2. For the USA, only data from 2006 to 2012 were available