Hinney A, Friedel S, Remschmidt H, Hebebrand J: Genetic risk factors in eating disorders. Am J Pharmacogenomics. 2004, 4: 209-223. 10.2165/00129785-200404040-00001.
Article
CAS
PubMed
Google Scholar
Monteleone P, Matias I, Martiadis V, De Petrocellis L, Maj M, Di Marzo V: Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. Neuropsychopharmacology. 2005, 30: 1216-1221. 10.1038/sj.npp.1300695.
Article
CAS
PubMed
Google Scholar
Bulik CM, Hebebrand J, Keski-Rahkonen A, Klump KL, Reichborn-Kjennerud T, Mazzeo SE, Wade TD: Genetic epidemiology, endophenotypes, and eating disorder classification. Int J Eat Disord. 2007, 40 (Suppl): S52-60. 10.1002/eat.20398.
Article
PubMed
Google Scholar
Klump KL, Miller KB, Keel PK, McGue M, Iacono WG: Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample. Psychol Med. 2001, 31: 737-740. 10.1017/S0033291701003725.
Article
CAS
PubMed
Google Scholar
Hebebrand J, Muller TD, Holtkamp K, Herpertz-Dahlmann B: The role of leptin in anorexia nervosa: clinical implications. Mol Psychiatry. 2007, 12: 23-35. 10.1038/sj.mp.4001909.
Article
CAS
PubMed
Google Scholar
Halmi KA: Eating disorders in females: genetics, pathophysiology, and treatment. J Pediatr Endocrinol Metab. 2002, 15 (Suppl 5): 1379-1386.
CAS
PubMed
Google Scholar
Støving RK, Andries A, Brixen K, Flyvbjerg A, Hørder K, Frystyk J: Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa. J Psychiatr Res. 2008
Google Scholar
Di Marzo V, Bifulco M, De Petrocellis L: The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004, 3: 771-784. 10.1038/nrd1495.
Article
CAS
PubMed
Google Scholar
Colombo G, Agabio R, Diaz G, Lobina C, Reali R, Gessa GL: Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci. 1998, 63: PL113-117. 10.1016/S0024-3205(98)00322-1.
Article
CAS
PubMed
Google Scholar
Liu YL, Connoley IP, Wilson CA, Stock MJ: Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. Int J Obes (Lond). 2005, 29: 183-187. 10.1038/sj.ijo.0802847.
Article
CAS
Google Scholar
Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G: Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 2001, 410: 822-825. 10.1038/35071088.
Article
CAS
PubMed
Google Scholar
van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rössner S, RIO-Europe Study Group: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005, 365: 1389-1397. 10.1016/S0140-6736(05)66374-X.
Article
CAS
PubMed
Google Scholar
Després JP, Golay A, Sjöström L, Rimonabant in Obesity-Lipids Study Group: Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med. 2005, 353: 2121-2134. 10.1056/NEJMoa044537.
Article
PubMed
Google Scholar
Hebebrand J, Exner C, Hebebrand K, Holtkamp C, Casper RC, Remschmidt H, Herpertz-Dahlmann B, Klingenspor M: Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol Behav. 2003, 79: 25-37. 10.1016/S0031-9384(03)00102-1.
Article
CAS
PubMed
Google Scholar
Exner C, Hebebrand J, Remschmidt H, Wewetzer C, Ziegler A, Herpertz S, Schweiger U, Blum WF, Preibisch G, Heldmaier G, Klingenspor M: Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa. Mol Psychiatry. 2000, 5: 476-481. 10.1038/sj.mp.4000771.
Article
CAS
PubMed
Google Scholar
Holtkamp K, Herpertz-Dahlmann B, Mika C, Heer M, Heussen N, Fichter M, Herpertz S, Senf W, Blum WF, Schweiger U, Warnke A, Ballauff A, Remschmidt H, Hebebrand J: Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa. J Clin Endocrinol Metab. 2003, 88: 5169-5174. 10.1210/jc.2003-030569.
Article
CAS
PubMed
Google Scholar
Holtkamp K, Hebebrand J, Herpertz-Dahlmann B: The contribution of anxiety and food restriction on physical activity levels in acute anorexia nervosa. Int J Eat Disord. 2004, 36: 163-171. 10.1002/eat.20035.
Article
PubMed
Google Scholar
Holtkamp K, Herpertz-Dahlmann B, Hebebrand K, Mika C, Kratzsch J, Hebebrand J: Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa. Biol Psychiatry. 2006, 60: 311-313. 10.1016/j.biopsych.2005.11.001.
Article
CAS
PubMed
Google Scholar
Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992, 258: 1946-1949. 10.1126/science.1470919.
Article
CAS
PubMed
Google Scholar
Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K: 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun. 1995, 215: 89-97. 10.1006/bbrc.1995.2437.
Article
CAS
PubMed
Google Scholar
Di Marzo V: Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators. Life Sci. 1999, 65: 645-655. 10.1016/S0024-3205(99)00287-8.
Article
CAS
PubMed
Google Scholar
Dinh TP, Freund TF, Piomelli D: A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids. 2002, 121: 149-158. 10.1016/S0009-3084(02)00150-0.
Article
CAS
PubMed
Google Scholar
Puffenbarger RA: Molecular biology of the enzymes that degrade endocannabinoids. Curr Drug Targets CNS Neurol Disord. 2005, 4: 625-631. 10.2174/156800705774933050.
Article
CAS
PubMed
Google Scholar
Hillard CJ, Wilkison DM, Edgemond WS, Campbell WB: Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. Biochim Biophys Acta. 1995, 1257 (3): 249-256.
Article
PubMed
Google Scholar
Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB: Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996, 384: 83-87. 10.1038/384083a0.
Article
CAS
PubMed
Google Scholar
Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH: Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA. 2001, 98: 9371-9376. 10.1073/pnas.161191698.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tsuboi K, Sun YX, Okamoto Y, Araki N, Tonai T, Ueda N: Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem. 2005, 280: 11082-11092. 10.1074/jbc.M413473200.
Article
CAS
PubMed
Google Scholar
Tsuboi K, Takezaki N, Ueda N: The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chem Biodivers. 2007, 4: 1914-1925. 10.1002/cbdv.200790159.
Article
CAS
PubMed
Google Scholar
Siegfried Z, Kanyas K, Latzer Y, Karni O, Bloch M, Lerer B, Berry EM: Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes. Am J Med Genet B Neuropsychiatr Genet. 2004, 125B: 126-130. 10.1002/ajmg.b.20089.
Article
CAS
PubMed
Google Scholar
Sipe JC, Waalen J, Gerber A, Beutler E: Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Int J Obes (Lond). 2005, 29: 755-759. 10.1038/sj.ijo.0802954.
Article
CAS
Google Scholar
Sipe JC, Chiang K, Gerber AL, Beutler E, Cravatt BF: A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Proc Natl Acad Sci USA. 2002, 99: 8394-8399. 10.1073/pnas.082235799.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang PW, Ishiguro H, Ohtsuki T, Hess J, Carillo F, Walther D, Onaivi ES, Arinami T, Uhl GR: Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. Mol Psychiatry. 2004, 9: 916-931. 10.1038/sj.mp.4001560.
Article
CAS
PubMed
Google Scholar
Hinney A, Lentes KU, Rosenkranz K, Barth N, Roth H, Ziegler A, Hennighausen K, Coners H, Wurmser H, Jacob K, Römer G, Winnikes U, Mayer H, Herzog W, Lehmkuhl G, Poustka F, Schmidt MH, Blum WF, Pirke KM, Schäfer H, Grzeschik KH, Remschmidt H, Hebebrand J: Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa. Int J Obes Relat Metab Disord. 1997, 21: 224-230. 10.1038/sj.ijo.0800391.
Article
CAS
PubMed
Google Scholar
American Psychiatric Association: Diagnostic and statistical manual of mental disorders (DSM-IV). 1994, Washington, DC, 539-549.
Google Scholar
Müller TD, Reichwald K, Wermter AK, Brönner G, Nguyen TT, Friedel S, Koberwitz K, Engeli S, Lichtner P, Meitinger T, Schäfer H, Hebebrand J, Hinney A: No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents. Mol Genet Metab. 2007, 90: 429-434. 10.1016/j.ymgme.2007.01.002.
Article
PubMed
Google Scholar
Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 1993, 52: 506-516.
PubMed Central
CAS
PubMed
Google Scholar
Comings DE, Muhleman D, Gade R, Johnson P, Verde R, Saucier G, MacMurray J: Cannabinoid receptor gene (CNR1): association with i.v. drug use. Mol Psychiatry. 1997, 2: 161-168. 10.1038/sj.mp.4000247.
Article
CAS
PubMed
Google Scholar
Covault J, Gelernter J, Kranzler H: Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. Mol Psychiatry. 2001, 6: 501-502. 10.1038/sj.mp.4000925.
Article
CAS
PubMed
Google Scholar
Gazzerro P, Caruso MG, Notarnicola M, Misciagna G, Guerra V, Laezza C, Bifulco M: Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population. Int J Obes (Lond). 2007, 31: 908-912. 10.1038/sj.ijo.0803510.
Article
CAS
Google Scholar
Peeters A, Beckers S, Mertens I, van Hul W, van Gaal L: The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men. Endocrine. 2007, 31: 138-141. 10.1007/s12020-007-0022-y.
Article
CAS
PubMed
Google Scholar
Benzinou M, Chèvre JC, Ward KJ, Lecoeur C, Dina C, Lobbens S, Durand E, Delplanque J, Horber FF, Heude B, Balkau B, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O, Meyre D, Froguel P: Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. Hum Mol Genet. 2008, 17: 1916-1921. 10.1093/hmg/ddn089.
Article
CAS
PubMed
Google Scholar
Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R: The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev. 2006, 27: 73-100. 10.1210/er.2005-0009.
Article
CAS
PubMed
Google Scholar
Poster DS, Penta JS, Bruno S, Macdonald JS: Delta 9-tetrahydrocannabinol in clinical oncology. JAMA. 1981, 245: 2047-2051. 10.1001/jama.245.20.2047.
Article
CAS
PubMed
Google Scholar
Gorter RW: Cancer cachexia and cannabinoids. Forsch Komplementarmed. 1999, 6 (Suppl 3): 21-22. 10.1159/000057152.
Article
PubMed
Google Scholar
Gross H, Ebert MH, Faden VB, Goldberg SC, Kaye WH, Caine ED, Hawks R, Zinberg N: A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa. J Clin Psychopharmacol. 1983, 3: 165-171. 10.1097/00004714-198306000-00004.
Article
CAS
PubMed
Google Scholar
Naruse T, Amano H, Koizumi Y: Possible involvement of dopamine D-1 and D-2 receptors in diazepam-induced hyperphagia in rats. Fundam Clin Pharmacol. 1991, 5: 677-693.
Article
CAS
PubMed
Google Scholar
Naruse T: Effects of repeated intravenous administration of diazepam on food intake in rats. Fundam Clin Pharmacol. 1994, 8: 379-384.
Article
CAS
PubMed
Google Scholar
Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Middeke K, Ziegler A, Roth H, Gerber G, Zamzow K, Ballauff A, Hamann A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt MH, Hermann H, Herpertz-Dahlmann BM, Fichter M, Remschmidt H, Hebebrand J: No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region. Mol Psychiatry. 1998, 3: 539-543. 10.1038/sj.mp.4000394.
Article
CAS
PubMed
Google Scholar
Quinton ND, Meechan DW, Brown K, Eastwood H, Blakemore AI: Single nucleotide polymorphisms in the leptin receptor gene: studies in anorexia nervosa. Psychiatr Genet. 2004, 14: 191-194. 10.1097/00041444-200412000-00004.
Article
CAS
PubMed
Google Scholar
Miyasaka K, Hosoya H, Sekime A, Ohta M, Amono H, Matsushita S, Suzuki K, Higuchi S, Funakoshi A: Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population. J Neural Transm. 2006, 113: 1279-1285. 10.1007/s00702-005-0393-2.
Article
CAS
PubMed
Google Scholar
Monteleone P, Tortorella A, Castaldo E, Di Filippo C, Maj M: No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa. Neurosci Lett. 2006, 398: 325-327. 10.1016/j.neulet.2006.01.023.
Article
CAS
PubMed
Google Scholar
Ribasés M, Gratacòs M, Armengol L, de Cid R, Badía A, Jiménez L, Solano R, Vallejo J, Fernández F, Estivill X: Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry. 2003, 8: 745-751. 10.1038/sj.mp.4001281.
Article
PubMed
Google Scholar
Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M, Cavallini MC, Cellini E, Di Bella D, Erzegovesi S, Foulon C, Gabrovsek M, Gorwood P, Hebebrand J, Hinney A, Holliday J, Hu X, Karwautz A, Kipman A, Komel R, Nacmias B, Remschmidt H, Ricca V, Sorbi S, Wagner G, Treasure J, Collier DA, Estivill X: Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet. 2004, 13: 1205-1212. 10.1093/hmg/ddh137.
Article
PubMed
Google Scholar
Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M, Cristina Cavallini M, Cellini E, Di Bella D, Erzegovesi S, Foulon C, Gabrovsek M, Gorwood P, Hebebrand J, Hinney A, Holliday J, Hu X, Karwautz A, Kipman A, Komel R, Nacmias B, Remschmidt H, Ricca V, Sorbi S, Tomori M, Wagner G, Treasure J, Collier DA, Estivill X: Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet. 2005, 13: 428-434. 10.1038/sj.ejhg.5201351.
Article
PubMed
Google Scholar
Friedel S, Horro FF, Wermter AK, Geller F, Dempfle A, Reichwald K, Smidt J, Brönner G, Konrad K, Herpertz-Dahlmann B, Warnke A, Hemminger U, Linder M, Kiefl H, Goldschmidt HP, Siegfried W, Remschmidt H, Hinney A, Hebebrand J: Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2005, 132B: 96-99. 10.1002/ajmg.b.30090.
Article
CAS
PubMed
Google Scholar
Ando T, Ishikawa T, Kawamura N, Karibe M, Oba M, Tatsuta N, Hara S, Takii M, Naruo T, Takei M, Kurokawa N, Nozoe S, Kubo C, Komaki G: Analysis of tumor necrosis factor-alpha gene promoter polymorphisms in anorexia nervosa. Psychiatr Genet. 2001, 11: 161-164. 10.1097/00041444-200109000-00009.
Article
CAS
PubMed
Google Scholar